Papers by Felice Petraglia
Journal of Endometriosis, Oct 1, 2010
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Gynecological Endocrinology, Jul 1, 2001
The aim of the present study was to determine a possible relationship between ovarian functionali... more The aim of the present study was to determine a possible relationship between ovarian functionality and regression of ovarian enlargement according to the different categories and degree of severity of ovarian hyperstimulation syndrome (OHSS). Among a group of sterile woman (n = 111), two subgroups were studied: group A (n = 15), patients affected by severe syndrome; and group B (n = 96), patients with massive ovarian enlargement only. The protocol of ovarian stimulation was conducted in various in vitro fertilization (IVF) centers; ultrasonographic examination and hematological checks were carried out daily; patients with severe OHSS were hospitalized. In women of group A, severe symptoms disappeared in 7-11 days; in nine patients with regular cycles ovary size returned to normal in about 30-40 days, whereas in six subjects with anovulatory cycles, the resolution was recorded in about 50-60 days; serum estradiol returned to physiological levels within 20-30 days. Women of group B showed a spontaneous regression at different times: in 43 subjects that presented regular ovulatory cycles, the resolution was recorded in about 30-40 days, whereas in 36 women with anovulatory cycles before pharmacological induction, resolution occurred in 50-60 days, and in 17 cases with polycystic ovary syndrome before pharmacological ovulation, an incomplete resolution was obtained; serum estradiol levels returned to a physiological range within 20-30 days. Our results show that in patients with regular ovulatory cycles, resolution of symptoms is obtained in a shorter time than in patients with anovulatory cycles before pharmacological induction.
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L Endocrinologo, Mar 14, 2014
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Advances in Experimental Medicine and Biology, Feb 1, 2003
Serum levels of tryptophan (Trp) and 5-hydroxytryptophan (5-HTP) were measured in the mother at b... more Serum levels of tryptophan (Trp) and 5-hydroxytryptophan (5-HTP) were measured in the mother at birth, by normal delivery or cesarean section, on days 1 and 3 post-partum, and in the cord blood of the fetus-newborns. Decreases in Trp and 5-HTP levels during delivery were noted. Conversely, Trp levels in the cord blood of fetus-newborns were significantly higher than those of their mothers, and 5-HTP levels also showed a tendency to increase , whereas on day 1 post-partum Trp values were lower than those in fetal cord, but higher than those during spontaneous delivery. On day 3 post-partum, serum Trp levels were higher than those during spontaneous delivery, but similar to those on day 1. 5-HTP values tended to decrease with respect to those of day 1. Serum Trp and 5-HTP concentrations decreased significantly on day 1 post-partum after cesarean section, but increased on day 3, demonstrating that maternal Trp was being consumed during delivery. A major release of prolactin in serum on days 1 and 3 post-partum there was in women with normal delivery, revealing a correlation between Trp and prolactin in the first few days after birth, in relation to different conditions of delivery.
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Fertility and Sterility, 1987
ABSTRACT
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Reproductive Sciences, Jul 1, 2009
Intrauterine infection is suggested to cause perinatal brain white matter injury. In the current ... more Intrauterine infection is suggested to cause perinatal brain white matter injury. In the current study, we evaluated whether S100B, a brain damage marker, may be also assessed in maternal bloodstream after white matter injury induced by fetal intravenous application of lypopolisaccharide (LPS) endotoxin. Fourteen fetal sheeps were chronically catheterized at a mean gestational age of 107 days. Three days after surgery, fetuses (n = 7) received 500 ng of LPS or 2 mL 0.9% saline (n = 7) intravenously (IV). Lypopolisaccharide and placebo groups were monitored by continuous hemodynamic data recordings and at 6 predetermined time points (control value; 3, 6, 24, 48, and 72 hours after LPS/placebo administration) blood was drawn for laboratory parameters and S100B assessment. Brain damage was evaluated by light microscopy after Klüver-Barrera staining. Selected areas of the periventricular white matter were also examined by electron microscopy. White matter injury was detected in all LPS-treated fetuses, whereas no abnormalities were seen in control animals or in LPS-treated mothers. Maternal and fetal S100B protein levels were significantly higher in the LPS group than in the control group at all monitoring time points (P < .001). The highest fetal-maternal S100B levels were observed at 3-hour time-point (P < .001). We found that S100B protein is increased in the maternal district in presence of fetal periventricular brain white matter injury induced by endotoxin. The present data offer additional support for S100B assessment in the maternal circulation in pregnancies complicated by intrauterine infection at risk of white matter injury.
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日本産科婦人科學會雜誌, Feb 1, 2007
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Italian Journal of Anatomy and Embryology, 2012
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Corticotropin-releasing factor (CRF) plays a key role in the mod- ulation of fetal-placental unit... more Corticotropin-releasing factor (CRF) plays a key role in the mod- ulation of fetal-placental unit function during human pregnancy. CRF has a potent vasoactive action on fetal-placental circulation. As prod- ucts secreted from endothelial cells affect vascular wall reactivity, we investigated whether cultured human umbilical vein endothelial cells (HUVEC) may represent a source and a target for CRF. With RT-PCR we
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European Journal of Obstetrics and Gynecology and Reproductive Biology, Jan 8, 2007
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Prenatal Diagnosis, Jun 1, 2009
... Research Letter. Urocortin in amniotic fluid and Down syndrome. Michela Torricelli 1 ,; Chiar... more ... Research Letter. Urocortin in amniotic fluid and Down syndrome. Michela Torricelli 1 ,; Chiara Voltolini 1 ,; Giulia Biliotti 1 ,; Claudio Giorlandino 2 ,; Flavio De Pascalis 1 ,; Maria De Bonis 1 ,; Alvaro Mesuraca 2 ,; ... 2 Artemisia Fetal-Maternal Medical Centre, Rome, Italy. ...
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Clinical Neuropharmacology, Nov 1, 1988
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Amer J Obstet Gynecol, 2007
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Human Reproduction, Oct 1, 1994
... Alessandro D.Genazzani1, Felice Petraglia, Mario Gastaldi, Cristina Volpogni, Ombretta Gamba,... more ... Alessandro D.Genazzani1, Felice Petraglia, Mario Gastaldi, Cristina Volpogni, Ombretta Gamba, Fausta Massolo2 and Andrea R.Genazzani ... Schally.AV, Arimura,A., Kastin,AJ, Matsuo.H.,Baba.Y., ReddingJ.W., Nair,RMG and Debeljuk,L. (1971) Gonadotropin-releasing ...
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Plos One, Feb 2, 2009
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Journal of Endocrinological Investigation, Mar 27, 2014
Allopregnanolone, a neuroactive steroid mainly secreted by adrenals and gonads, is a hormone that... more Allopregnanolone, a neuroactive steroid mainly secreted by adrenals and gonads, is a hormone that seems to play a role in precocious puberty, as demonstrated by its high baseline levels found in girls with central precocious puberty (CPP). Allopregnanolone concentrations significantly increase after GnRH and ACTH stimulation test suggesting both its ovarian and adrenal production. Aim of this study was to evaluate allopregnanolone concentrations after GnRH and GnRH agonist analog stimulation test in girls with CPP to better establish its secretion source. Gonadotropins and steroid hormones were evaluated in different days after GnRH and triptorelin stimulation test in 15 CPP girls. After GnRH stimulation, LH, FSH, and allopregnanolone concentrations significantly increased (p<0.05). After triptorelin administration LH, FSH, estradiol and DHEAS levels significantly increased (p<0.05), while allopregnanolone concentrations significantly decreased (1.08±0.24 vs 0.87±0.28 nmol/l; p=0.003). The different response of allopregnanolone to GnRH and GnRH agonist analog might reflect the agonist and antagonist action exerted by these secretagogues. Our data suggest the prevalent gonadal allopregnanolone production in CPP subjects and the usefulness of its measurement in the diagnosis of CPP.
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Papers by Felice Petraglia