Papers by Garth Dickinson
PubMed, Apr 15, 1993
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PubMed, Feb 1, 1989
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Survey of Anesthesiology, Apr 1, 1994
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Canadian Medical Association Journal, Jun 15, 1985
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Canadian Medical Association Journal, Jul 1, 1996
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Canadian Journal of Emergency Medicine, Oct 1, 2001
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Prehospital and Disaster Medicine, 2003
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Canadian Journal of Emergency Medicine, May 1, 2010
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The New England Journal of Medicine, Jun 26, 2003
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Annals of Emergency Medicine, Nov 1, 1992
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Annals of Emergency Medicine, Oct 1, 2008
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The Journal of Clinical Pharmacology, Apr 1, 1989
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Annals of Emergency Medicine, Nov 1, 1989
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American Heart Journal, Jun 1, 2010
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Europace, Jan 29, 2012
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The Canadian Journal of Hospital Pharmacy, 2005
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International Journal of Cardiology, Jun 1, 2013
Vernakalant is a novel, relatively atrial-selective antiarrhythmic drug. This analysis assessed t... more Vernakalant is a novel, relatively atrial-selective antiarrhythmic drug. This analysis assessed the efficacy and safety of intravenous vernakalant for the rapid conversion of atrial fibrillation (AF) to sinus rhythm in patients with a history of ischemic heart disease (IHD). The presence of IHD was extracted from the medical history of patients from four randomized placebo-controlled studies and one open label study. The efficacy analysis included patients with recent onset AF (consistent with the European labeled indication), while the safety analysis included all patients with AF or atrial flutter (AFL) (3h to 45 days duration) who were exposed to study drug. A total of 1052 adult patients were enrolled and treated; 274 patients (91 placebo, 183 vernakalant) with a history of IHD and 778 patients (224 placebo, 554 vernakalant) without IHD. Conversion of AF to sinus rhythm was not influenced by IHD. In patients with recent onset AF, the placebo-subtracted conversion rate with vernakalant was 45.7% in the IHD group and 47.3% in the non-IHD group. In the 24h following treatment, the rate of treatment-emergent serious adverse events and discontinuations due to adverse events was similar in both the IHD and non-IHD groups, and there was no case of torsades de pointes, ventricular fibrillation, or death in patients with IHD. Vernakalant was safe and well tolerated in AF/AFL patients with a history of IHD, and was significantly more effective than placebo for the acute conversion of AF regardless of IHD status.
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Emergency Medicine Journal, Nov 1, 2003
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Chest, Aug 1, 1990
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Chest, Apr 1, 2003
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Papers by Garth Dickinson