Papers by Bambang Veriansyah
International Journal of Pharmacy and Pharmaceutical Sciences, Feb 1, 2016
Objective: This present study aims to produce cocrystal of paracetamol (PCA)-dipicolinic acid (DP... more Objective: This present study aims to produce cocrystal of paracetamol (PCA)-dipicolinic acid (DPA) using supercritical antisolvent (SAS) cocrystallization process in order to improve tabletability profile of PCA. Methods: The PCA-DPA cocrystal prepared by SAS cocrystallization were compared to those produced using a traditional solvent evaporation. The cocrystals produced were characterized using Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Polarized Light Microscopy (PLM), Fourier Transform Infrared (FTIR) spectroscopy, particle size analysis, Scanning Electron Microscopy (SEM) and High Performance Liquid Chromatography (HPLC). Analysis of flowability, drug content, solubility, dissolution, stability and powder compaction were performed to evaluate the cocrystals. Results: Cocrystal particles with mean diameter of 4.18 µm were produced from SAS process, smaller than those produced by traditional solvent evaporation method (mean diameter of 64.93 μm). The PCA-DPA cocrystal from SAS process showed an enhanced dissolution rate by 2.45 times compared to PCA, higher than cocrystal from traditional solvent evaporation (enhanced dissolution rate by 1.72 times compared to PCA). Tabletability study revealed superior tableting performance of both cocrystals compared to PCA. Conclusion: This study showed the utility of PCA-DPA cocrystal to improve mechanical properties of PCA while also demonstrating that simultaneous micronization and cocrystallization process can be obtained using SAS process.
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Asean Journal of Chemical Engineering, Jan 6, 2004
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Journal of Environmental Science and Health Part a Toxic Hazardous Substances Environmental Engineering, Nov 10, 2009
Continuous catalytic hydrodechlorination of polychlorinated biphenyls (PCBs) in the presence of t... more Continuous catalytic hydrodechlorination of polychlorinated biphenyls (PCBs) in the presence of transformer oils was carried out in a fixed bed reactor using a 57.6 wt% Ni on silicon oxide-aluminum oxide (SiO(2)-Al(2)O(3)) catalyst. Reaction temperatures ranging 150-300 degrees C, PCBs concentrations ranging 50-200 ppm, and reaction times ranging 1-8 h were tested. At a higher reaction temperature or at a lower PCBs concentration, catalytic activity was higher and complete dechlorination of PCBs resulted even at long reaction time. Catalyst regeneration using hexane and 0.1 M sodium hydroxide (NaOH) was effective to restore the catalytic activity. Fresh, spent and regenerated catalysts were characterized by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis. XRD analysis revealed growth of Ni crystallite size of the spent and the regenerated catalysts. XPS analysis showed that a considerable amount of chlorine and carbon species were deposited on the surface of the spent catalyst, which may play a role in the catalysts deactivation.
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AAPS PharmSciTech, 2016
We report novel pharmaceutical salts of an anti-hypertensive drug carvedilol (CVD) with pharmaceu... more We report novel pharmaceutical salts of an anti-hypertensive drug carvedilol (CVD) with pharmaceutically acceptable salt formers, including oxalic acid (OXA), fumaric acid (FUMA), benzoic acid (BZA), and mandelic acid (MDA) via conventional solvent evaporation technique. The pKa difference between CVD and selected acids was greater than 3, thus suggesting salt formation. Two polymorphic forms of CVD/MDA salts and one p-Dioxane solvate of CVD/FUMA salt were also reported in this paper. The salts were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Stability of the salts was assessed by storage at 40°C/75% RH for 1 month. All CVD salts exhibited higher solubility in phosphate buffer solution pH 6.8 compared to the parent drug CVD and showed good stability in accelerated ICH conditions at 40°C/75% RH for 1 month. CVD/FUMA salt showed the highest solubility (1.78 times). Based on thermal analysis and slurry experiment, it was found that CVD/MDA polymorphs were related monotropically with Form 1 as the stable form. The results suggested that salt formation could be an alternative method to improve CVD solubility.
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The Journal of Supercritical Fluids, 2009
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The Journal of Supercritical Fluids, 2016
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Chemical Engineering Journal, Apr 1, 2011
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The Journal of Supercritical Fluids, Feb 1, 2010
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Bioresource Technology, Nov 1, 2010
This study examined the synthesis of biodiesel using supercritical or subcritical methanol with m... more This study examined the synthesis of biodiesel using supercritical or subcritical methanol with metal oxide catalysts. The transesterification of rapeseed oil was carried out with the metal oxide catalysts (SrO, CaO, ZnO, TiO(2) and ZrO(2)) to determine the most effective heterogeneous catalyst having the highest catalytic activity with minimum weight loss caused by dissolution. SrO and CaO dissolved in the biodiesel during the reaction because they were transformed to strontium methoxide and calcium methoxide, respectively. ZnO was the optimum catalyst for the transesterification of rapeseed oil owing to its high activity and minimum weight loss in supercritical methanol. The optimal reaction conditions included a molar ratio of methanol to oil of 40 in the presence of 1.0wt.% ZnO and a reaction time of 10min. The supercritical process with ZnO as a catalyst appears economically viable.
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International Journal of Hydrogen Energy, Mar 1, 2010
A new design of supercritical water gasification system was developed to achieve high hydrogen ga... more A new design of supercritical water gasification system was developed to achieve high hydrogen gas yield and good gas–liquid flow stability. The apparatus consisted of a reaction zone, an insulation zone and a cooling zone that were directly connected to the reaction ...
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Journal of Environmental Sciences
Supercritical water oxidation (SCWO) has been drawing much attention due to effectively destroy a... more Supercritical water oxidation (SCWO) has been drawing much attention due to effectively destroy a large variety of high-risk wastes resulting from munitions demilitarization and complex industrial chemical. An important design consideration in the development of supercritical water oxidation is the information of decomposition rate. In this paper, the decomposition rate of dimethyl methylphosphonate (DMMP), which is similar to the nerve agent VX and GB (Sarin) in its structure, was investigated under SCWO conditions. The experiments were performed in an isothermal tubular reactor with a H2O2 as an oxidant. The reaction temperatures were ranged from 398 to 633 degrees C at a fixed pressure of 24 MPa. The conversion of DMMP was monitored by analyzing total organic carbon (TOC) on the liquid effluent samples. It is found that the oxidative decomposition of DMMP proceeded rapidly and a high TOC decomposition up to 99.99% was obtained within 11 s at 555 degrees C. On the basis of data derived from experiments, a global kinetic equation for the decomposition of DMMP was developed. The model predictions agreed well with the experimental data.
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ABSTRACT
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International Journal of Pharmacy and Pharmaceutical Sciences
Objective: Pharmaceutical salt and cocrystal is a promising alternative method for improving the ... more Objective: Pharmaceutical salt and cocrystal is a promising alternative method for improving the solubility and dissolution rate of active pharmaceutical ingredients. In this work, an attempt was made to improve solubility of ketoconazole (KTZ) using salt formation and cocrystallization technique. Methods: Salt and cocrystal were prepared using oxalic acid (OXA) and fumaric acid (FUMA) via slurry conversion method. Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscope (SEM) techniques were employed to investigate the crystallinity, melting point and morphology of salt and cocrystal respectively. KTZ salt and cocrystal were evaluated further for their solubility, stability and antifungal activities. Results: Synthesis of KTZ OXA salt and KTZ FUMA cocrystal were successfully carried out using slurry conversion method using ethyl acetate solvent. The result from PXRD, DSC and SEM analysis confirms the formation of salt and cocrystal o...
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Micronization of ibuprofen using bottom-up process via rapid expansion of supercritical solution ... more Micronization of ibuprofen using bottom-up process via rapid expansion of supercritical solution (RESS) were conducted to investigate its effects on formation of micronized ibuprofen. Physicochemical properties of processed ibuprofen were analyzed using XRD, DSC, FT-IR, SEM, laser diffractometer and dissolution testing. Effects of extraction pressure, extraction temperature and nozzle diameter on particle size were optimized using Taguchi's orthogonal array and analyzed using analysis of variance (ANOVA). Processed ibuprofen retained its crystalline structure and has a similar chemical structure with unprocessed ibuprofen. The average particle size of ibuprofen was reduced from its original 48.549±2.304 µm into 3.765±0.024 µm under the optimum condition (T at 45 o C, P at 200 bar and nozzle diameter at 200 µm). The processed ibuprofen showed an enhanced its dissolution rate by 1.79 times compare to unprocessed ibuprofen.
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Journal of environmental sciences (China), 2006
Supercritical water oxidation (SCWO) has been drawing much attention due to effectively destroy a... more Supercritical water oxidation (SCWO) has been drawing much attention due to effectively destroy a large variety of high-risk wastes resulting from munitions demilitarization and complex industrial chemical. An important design consideration in the development of supercritical water oxidation is the information of decomposition rate. In this paper, the decomposition rate of dimethyl methylphosphonate (DMMP), which is similar to the nerve agent VX and GB (Sarin) in its structure, was investigated under SCWO conditions. The experiments were performed in an isothermal tubular reactor with a H2O2 as an oxidant. The reaction temperatures were ranged from 398 to 633 degrees C at a fixed pressure of 24 MPa. The conversion of DMMP was monitored by analyzing total organic carbon (TOC) on the liquid effluent samples. It is found that the oxidative decomposition of DMMP proceeded rapidly and a high TOC decomposition up to 99.99% was obtained within 11 s at 555 degrees C. On the basis of data de...
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