Papers by Mitali Chatterjee
Over six million people in nine districts of West Bengal,
India are exposed to very high levels o... more Over six million people in nine districts of West Bengal,
India are exposed to very high levels of arsenic primarily
through their drinking water. More than 300,000 people
showed arsenic-induced skin lesions in these districts.
This is regarded as the greatest arsenic calamity in the
world. Chronic arsenicosis causes varied dermatological
signs ranging from pigmentation changes, hyperkeratosis
to non-melanocytic cancer of skin, and also malignancies
in different internal organs. Higher incidences of opportunistic
infections are found in the arsenic-exposed individuals,
indicating that their immune systems may be
impaired somehow. We have thus investigated the effect
of arsenic on T-cell proliferation and cytokine secretion
in 20 individuals with arsenic-induced skin lesions and
compared the results with 18 arsenic-unexposed individuals.
A marked dose-dependent suppression of Concanavalin
A (Con A) induced T-cell proliferation was
observed in the arsenic-exposed individuals compared
with the unexposed (P < 0.001) individuals. This correlated
with a significant decrease in the levels of secreted
cytokines by the T cells (TNF-α, IFN-γ, IL2, IL10, IL5, and
IL4) in the exposed individuals (P < 0.001). Thus it can be
inferred that arsenic exposure can cause immunosuppression
in humans.
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Journal of medical …, 2007
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Journal of immunological methods, 2002
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Journal of immunological methods, 2005
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Toxicology, Jan 18, 2008
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Bioorganic & medicinal chemistry letters, Jan 15, 2011
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Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2011
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Glycoconjugate Journal - GLYCOCONJUGATE J, 2007
Aloe vera has wide spread use in health products, and despite several reports on the whole plant ... more Aloe vera has wide spread use in health products, and despite several reports on the whole plant and inner gel, little work has been performed on the leaf exudate. Our aim was to evaluate the in vitro efficacy of Aloe vera leaf exudate (AVL) in leishmaniasis. Irrespective of the disease manifestation, promastigotes from strains responsible for cutaneous, mucocutaneous, and visceral leishmaniasis were susceptible to AVL and their IC50 ranged from 100 to 180 μg/ml. In axenic amastigotes cultured from a L. donovani strain 2001 responsible for visceral leishmaniasis, the IC50 was 6.0 μg/ml. AVL caused activation of host macrophages evident by an increased release of members of reactive oxygen species that was attenuated by preincubation with free radical scavengers. Collectively, our data indicates that AVL, via its direct leishmanicidal activity which can be further enhanced by activation of host macrophages, is an effective antileishmanial agent meriting further pharmacological investigations.
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Bioorganic & Medicinal Chemistry Letters - BIOORG MEDICINAL CHEM LETTER, 2010
A series of analogues of andrographolide, prepared through chemo-selective functionalization at C... more A series of analogues of andrographolide, prepared through chemo-selective functionalization at C14 hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the analogues (6a, 9b) exhibited significant potency. Preliminary studies on structure–activity relationship (SAR) revealed that the α-alkylidene-γ-butyrolactone moiety of andrographolide played a major role in the activity profile. The structures of the analogues were established through spectroscopic and analytical dataA series of analogues of andrographolide, prepared through chemo-selective functionalization at C14 hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the analogues (6a, 9b) exhibited significant potency. Preliminary studies on structure–activity relationship (SAR) revealed that the α-alkylidene-γ-butyrolactone moiety of andrographolide played a major role in the activity profile. The structures of the analogues were established through spectroscopic and analytical data.
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Phytotherapy Research, 2007
A major problem in the management of visceral leishmaniasis, especially in the Indian subcontinen... more A major problem in the management of visceral leishmaniasis, especially in the Indian subcontinent, is the growing unresponsiveness to conventional antimonial therapy, indicating the urgent need to identify new antileishmanial compounds. This study was undertaken to evaluate the antileishmanial activity of the fruit rind of Myristica malabarica that is used as a spice and is also credited with medicinal properties. The antipromastigote activity of different extracts/fractions of M. malabarica and its constituent diarylnonanoids were evaluated in Leishmania donovani promastigotes (MHOM/IN/83/AG83) using the MTS-PMS assay. Preliminary screening of the ether extract (R1) with its crude methanol fraction (R2) and two fractions (R3 and R4) revealed that R2 had potent leishmanicidal activity (IC50 31.0 µg/mL), whereas R3 and R4 showed poor activity. Fractionation of R2 yielded four diarylnonanoids (malabaricones A–D, designated as Mal A, Mal B, Mal C and Mal D, respectively). The IC50 values of Mal A–D were 16, 22, 27 and >50 µg/mL, respectively. Taken together, the data suggest that the methanol extract of M. malabarica, especially its constituent compounds, Mal A and Mal B, have promising antileishmanial activity meriting further investigations regarding the underlying molecular mechanism(s) of action with a view towards future drug development. Copyright © 2007 John Wiley & Sons, Ltd.
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International Journal of Antimicrobial Agents, 2010
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Trends in Parasitology, 2014
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Papers by Mitali Chatterjee
India are exposed to very high levels of arsenic primarily
through their drinking water. More than 300,000 people
showed arsenic-induced skin lesions in these districts.
This is regarded as the greatest arsenic calamity in the
world. Chronic arsenicosis causes varied dermatological
signs ranging from pigmentation changes, hyperkeratosis
to non-melanocytic cancer of skin, and also malignancies
in different internal organs. Higher incidences of opportunistic
infections are found in the arsenic-exposed individuals,
indicating that their immune systems may be
impaired somehow. We have thus investigated the effect
of arsenic on T-cell proliferation and cytokine secretion
in 20 individuals with arsenic-induced skin lesions and
compared the results with 18 arsenic-unexposed individuals.
A marked dose-dependent suppression of Concanavalin
A (Con A) induced T-cell proliferation was
observed in the arsenic-exposed individuals compared
with the unexposed (P < 0.001) individuals. This correlated
with a significant decrease in the levels of secreted
cytokines by the T cells (TNF-α, IFN-γ, IL2, IL10, IL5, and
IL4) in the exposed individuals (P < 0.001). Thus it can be
inferred that arsenic exposure can cause immunosuppression
in humans.
India are exposed to very high levels of arsenic primarily
through their drinking water. More than 300,000 people
showed arsenic-induced skin lesions in these districts.
This is regarded as the greatest arsenic calamity in the
world. Chronic arsenicosis causes varied dermatological
signs ranging from pigmentation changes, hyperkeratosis
to non-melanocytic cancer of skin, and also malignancies
in different internal organs. Higher incidences of opportunistic
infections are found in the arsenic-exposed individuals,
indicating that their immune systems may be
impaired somehow. We have thus investigated the effect
of arsenic on T-cell proliferation and cytokine secretion
in 20 individuals with arsenic-induced skin lesions and
compared the results with 18 arsenic-unexposed individuals.
A marked dose-dependent suppression of Concanavalin
A (Con A) induced T-cell proliferation was
observed in the arsenic-exposed individuals compared
with the unexposed (P < 0.001) individuals. This correlated
with a significant decrease in the levels of secreted
cytokines by the T cells (TNF-α, IFN-γ, IL2, IL10, IL5, and
IL4) in the exposed individuals (P < 0.001). Thus it can be
inferred that arsenic exposure can cause immunosuppression
in humans.