Papers by Costantino Renzis
…, 2010
Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Neurosurgery. Ent... more Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Neurosurgery. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining ...
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Neuro-Oncology, 2012
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Neurosurgical FOCUS, 2009
Glioblastoma multiforme (GBM) is a devastating malignant brain tumor characterized by resistance ... more Glioblastoma multiforme (GBM) is a devastating malignant brain tumor characterized by resistance to available therapeutic approaches and relentless malignant progression that includes widespread intracranial invasion, destruction of normal brain tissue, progressive disability, and death. Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) are increasingly used in patients with recurrent GBM to complement traditional treatments such as resection, conventional external beam radiotherapy, and chemotherapy. Both SRS and fSRT are powerful noninvasive therapeutic modalities well suited to treat focal neoplastic lesions through the delivery of precise, highdose radiation. Although no randomized clinical trials have been performed, a variety of retrospective studies have been focused on the use of SRS and fSRT for recurrent GBMs. In addition, state-of-the-art neuroimaging techniques, such as MR spectroscopic imaging, diffusion tensor tractography, and nuclear medicine imaging, have enhanced treatment planning methods leading to potentially improved clinical outcomes. In this paper the authors reviewed the current applications and efficacy of SRS and fSRT in the treatment of GBM, highlighting the value of these therapies for recurrent focal disease.
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Aims. To quantify radiation treatments for bone metastases from breast cancer in three Sicilian p... more Aims. To quantify radiation treatments for bone metastases from breast cancer in three Sicilian provinces (Messina, Catania, Ragusa) with respect to the general population and the incidence and prevalence of breast cancer in this macro-area in a 8-year period.
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Annali italiani di chirurgia
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Journal of X-ray science and technology, 2015
Purpose of this work was to study the dose perturbation within the target volume of a external MV... more Purpose of this work was to study the dose perturbation within the target volume of a external MV radiation therapy when using metal fiducials. We developed a Monte Carlo simulation in Geant4 of a cylindrical fiducial made either of gold or of steel and simulated the photon irradiation beam originating from a medical Linac operating at 6, 10 or 15 MV. For each energy, two different irradiation schemes were simulated: a single 5 × 5-cm square field in the -x direction, and five 5 × 5-cm fields at 0°, 80°, 165°, 195° and 280°. In a single beam irradiation scheme, we observed a dose reduction behind fiducials varying from -20% for gold at 6 MV to -5% for steel at 15 MV, and a dose increment in front of the fiducial ranging from +33% for gold at 15 MV to +10% for steel at 6 MV. When five beams were employed, a dose increment ranging from +28% to +46% has been found around gold. Around a steel fiducial, an average increment of +17% was found, irrespective of the photon energy. When using...
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Anticancer research, 2014
Basal cell carcinoma (BCC) is the most common malignant periocular tumor. When periorbital invasi... more Basal cell carcinoma (BCC) is the most common malignant periocular tumor. When periorbital invasion exists, orbital exenteration is necessary. A 73-year-old man with recurrent BCC of the inner canthus of the left eye with diffusion to the extrinsic muscles of the orbit and periorbital fat was treated with CyberKnife in stereotactic body radiation therapy (SBRT) modality. The treatment resulted in rapid tumor regression, with a complete remission after six months without toxicities. To the best of our knowledge, this is the first report in the English literature describing a locally advanced BCC treated with SBRT alone.
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World journal of gastroenterology : WJG, Jan 14, 2007
To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-in... more To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d.,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P<0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P<0.001). Daily bowel movements were 14.7 +/- 6 and 5.1 +/- 3 a...
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Tumori
There is no standard treatment for elderly-unfit patients with muscle-invasive bladder cancer. Pe... more There is no standard treatment for elderly-unfit patients with muscle-invasive bladder cancer. Pelvic irradiation alone is an usual approach in this instance, and some reports have demonstrated that curative radiotherapy is feasible in elderly patients. To our knowledge, no data exist about the feasibility of a curative treatment in elderly patients with concomitant illness and a Charlson Comorbidity Index (an index of comorbidity that includes age) greater than 2. The main purpose of the present study was to establish the feasibility of irradiation in a cohort of elderly patients in poor general condition. The records of 45 elderly-unfit patients (median age, 75 years; range, 70-85), with a comorbid Charlson score >2, treated with curative dose, planned continuous-course, external beam radiotherapy for muscle-invasive bladder cancer were reviewed. The patients were treated to a median total dose of 60 Gy (range, 56-64), with an average fractional dose of 190 +/- 10 cGy using meg...
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Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 2001
To define the role of radiotherapy (RT) in the treatment of ipsilateral supraclavicular lymph-nod... more To define the role of radiotherapy (RT) in the treatment of ipsilateral supraclavicular lymph-nodes metastases (ISLM) from breast cancer as only site of disseminated disease, we started a prospective non-randomized clinical trial in 1989. Here we report the final results with a median follow-up of 8.75 years. Thirty-seven patients (pts), with ISLM from breast cancer, were consecutively enrolled into two arms. Arm A (18 pts): chemotherapy (CT) for six courses. Arm B (19 pts): CT for three courses followed by RT to the site of ISLM at 'radical' dose of 50-60 Gy. In arm A, a median Time to Progression (TtP) of 7 months with a median Overall Survival (OS) of 28 months was recorded. In comparison, patients in arm B had a longer median TtP with 20 months as well as a better median OS with 41 months, respectively. An actuarial five-year disease-free survival of 5.5% was obtained in arm A vs. 21% in arm B. A statistically significant difference in TtP was demonstrated between the tw...
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La Radiologia medica, 1994
Lumbosacral carcinomatous neuropathy (LCN) may be caused by infiltration or compression of the lu... more Lumbosacral carcinomatous neuropathy (LCN) may be caused by infiltration or compression of the lumbosacral plexi and nerves from intrapelvic or paraaortic neoplasms. The authors submitted 23 patients complaining of LCN with CT documented intrapelvic or paraaortic tumors to palliative radiotherapy. Megavoltage external beam irradiation was administered using a 6-MV linear accelerator. Treatment field sizes ranged from 56 cm2 to 235 cm2 (mean: 150.54 cm2) and encompassed only the site where the disease involved the lumbosacral plexus or its branches. > or = 3 Gy/day fractions were used. Twenty-one of 22 assessable patients (95.4%) obtained LCN pain relief; 19 (86.3%) obtained complete LCN pain relief. The median time to pain progression (TPP) was 150 days (range: 39-510 days). The median survival was 165 days. Seven patients were LCN pain-free at death. Two patients are alive and LCN pain-free. The remaining 12 patients had recurrent LCN pain: four of them were reirradiated at the ...
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Rays
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Radiotherapy and Oncology, 2010
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INTRODUZIONE Nei pazienti sottoposti a radioterapia sul di-stretto pelvico è frequente il riscont... more INTRODUZIONE Nei pazienti sottoposti a radioterapia sul di-stretto pelvico è frequente il riscontro di un ef-fetto collaterale piuttosto ingravescente quale la diarrea che, oltre a peggiorare la qualità di vita del paziente, può in casi estremi comportare l'in-terruzione del trattamento radiante stesso. La diarrea in genere insorge dopo 2 settima-ne circa dall'inizio del trattamento, è correlata con l'entità della dose per frazione e con il volu-me irradiato. Il tratto intestinale più radiosensibi-le è costituito dall'epitelio del tenue. Infatti, an-che in seguito a dosi radioterapiche modeste, si verifica un precoce malassorbimento dei grassi e una ipermotilità intestinale. Entro alcune ore dal-l'irradiazione cessa l'attività proliferativa a livello delle cripte (nel loro terzo medio) e sono eviden-ziabili necrosi cellulari con picnosi, carioressi, ca-riolisi ed accumulo dei detriti nel lume criptico 1 . La reazione iniziale è precoce e può avveni-re in cors...
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SpringerPlus, 2015
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To quantify radiation treatments for bone metastases from breast cancer in three Sicilian provinc... more To quantify radiation treatments for bone metastases from breast cancer in three Sicilian provinces (Messina, Catania, Ragusa) with respect to the general population and the incidence and prevalence of breast cancer in this macro-area in a 8-year period. All bone metastasis patients treated using radiotherapy in 8 radiation departments operating in the provinces of Messina, Catania and Ragusa were collected. Among these, metastases from breast carcinoma were analyzed according to year of irradiation. An analysis of breast cancer incidence and prevalence with respect to inhabitants in this macro-area was conducted using literature and census data. From January 2004 to December 2011, irradiation was delivered in 4419 bone metastasis patients. Among these, 1617 had a primary breast cancer with a median treatment per year of 206.5 (range, 164-251); 211 patients were treated in 2004 and 206 in 2011. In 2004, there were 1,048,957 female residents in the three provinces and 1,065,422 in 20...
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Papers by Costantino Renzis