Papers by Ratnakaram Venkata Nadh
Journal of Molecular Structure
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viXra, 1998
Kinetic Studies of thiocyanate and iodide oxidation with 2,6-dichloro-quinone-4-chloro-imide: A n... more Kinetic Studies of thiocyanate and iodide oxidation with 2,6-dichloro-quinone-4-chloro-imide: A novel and a new oxidising agent,
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International Journal of PharmTech Research
An accurate, sensitive, precise and robust reverse phase high performance liquid chromatographic ... more An accurate, sensitive, precise and robust reverse phase high performance liquid chromatographic (RP-HPLC) method for the estimation of Febuxostat in bulk forms has been developed and validated. Chromatographic separation is conducted on Nucleosil C18 (250 x 4.6mm, 5μm) column at ambient temperature using mixture of 10 mM ammonium acetate buffer (buffer of pH 4.0 adjusted with 0.2% triethyl amine) and acetonitrile in the ratio (15: 85, v/v) as a mobile phase and at a flow rate of 1.2 ml / min, while UV detection is performed at 275nm. The retention time for Febuxostat is found to be 3.45 ± 0.05 min. The method is found to be linear in the range of 50.0 – 400.0 μg/mL. The limit of detection and quantization for Febuxostat are found to be 9.98 and 30.23 μg /mL respectively. Analytical recovery is 99.29 %. The percentage RSD for precision and accuracy of the method is found to be less than 2%. The method is validated as per the ICH guidelines and applied for the quantitative analysis o...
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Analytical Methods, 2014
An isocratic reversed phase ultra performance liquid chromatography (RP-UPLC) method was develope... more An isocratic reversed phase ultra performance liquid chromatography (RP-UPLC) method was developed for screening counterfeit medicines with UV detection at 210 nm.
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viXra, 2019
Caralluma is a genus used as traditional medicine. Caralluma lasiantha is medicinally important d... more Caralluma is a genus used as traditional medicine. Caralluma lasiantha is medicinally important due to existence of pregnane glycosides, which may possess various biological activities. This article thoroughly reviewed about the usage of C. lasiantha in traditional medicinal system, phytochemicals present in it, profile identification studies, anti-hyperglycemic effect, antibacterial, antifungal, cytotoxic and antioxidant activities.
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International Journal of Research in Pharmaceutical Sciences, 2018
Caralluma is one of the prominent genus out of 200 genera and 2500 species of Asclepiadaceae fami... more Caralluma is one of the prominent genus out of 200 genera and 2500 species of Asclepiadaceae family. Caralluma genus belongs to Asclepiadaceae and is widely distributed in Asia countries, Africa, Arabian Peninsula, Canary Islands and Southeast Europe. In folkloric medicine, as well as in Unani and Ayurvedic systems of medicine, the plants of Caralluma are being used for the treatment of diabetic patients and rheumatism. Tribals consider some of them as food during famines and also as a part of the traditional medicinal system. In India and Pakistan, Caralluma species have been used as emergency foods for the last few centuries. As allopathic medicines possess toxic nature and side effects, the use of plant-based medicine is becoming popular. This lead to a sudden enhancement in the production of herbal drugs. At present Caralluma is gaining much importance from researchers because it possesses array immunostimulating activities due to presence flavonoids and saponins and pregnane gl...
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Asian Journal of Pharmaceutics, 2018
Aim: The objective of the current study is to develop a colorimetric method for the determination... more Aim: The objective of the current study is to develop a colorimetric method for the determination of mianserin, an antidepressant drug. Materials and Methods: Fast Sulphon Black F, an acidic dye was used to develop a soluble colored ion-pair complex. The complex was extracted into an organic solvent and absorbance was measured. Results: Reaction conditions were optimized to obtain a sensitive and stable chromophore (λmax 554 nm) in dichloromethane. Good linearity was observed for the calibration curve plotted in the studied concentration range (4–14 μg/mL) with regression analysis (r > 0.9997). High percentage recovery values (98.25–101.40) show that the method is accurate. Reproducibility of the method is evident from lower relative standard deviation (<2%) for both intra- and inter-day precision studies. Conclusions: The proposed method is validated as per the existing ICH guidelines. This method is simple as it does not require any pre-treatment process.
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Aim and Objective: The aim and objective of this study were to develop a spectrophotometric metho... more Aim and Objective: The aim and objective of this study were to develop a spectrophotometric method for the assay of selexipag (selective IP prostacyclin receptor agonist indicated for the treatment of pulmonary arterial hypertension) in pure and pharmaceutical formulations so that it will be an alternative quantitative method to chromatographic methods which require large quantities of organic solvents, where some are with hazardous and toxic properties. Materials and Methods: The method is based on the diazo coupling of selexipag with diazotized p-nitroaniline in alkaline medium to form a stable green-colored and water-soluble azo dye with a maximum absorption at 510 nm. Optimization of reaction conditions was carried out to get highly sensitive and stable colored complex. Results and Discussion: Beer’s law is obeyed over the concentration range of 2–12 μg/mL with a molar absorptivity of 3.33 × 104 L/mol/cm. The limit of detection was 0.35 μg/mL and limit of quantification was 1.0 ...
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Asian Journal of Chemistry, 2020
Roflumilast is a selective enzyme inhibitor of phosphodiesterase-4. This drug is recommended for ... more Roflumilast is a selective enzyme inhibitor of phosphodiesterase-4. This drug is recommended for treatment of patients suffering from chronic-obstructive-pulmonary-disease with chronic-bronchitis. Roflumilast is not official in pharmacopoeia and the reported methods are having high chromatographic run times. A short run time HPLC method was developed for assay and content uniformity testing to determine the roflumilast in blend and tablets. The mobile phase consists of 10 mM sodium dihydrogen phosphate monohydrate buffer and acetonitrile in the ratio of 45:55 v/v. The HPLC method was developed using accucore-C18 150 × 4.6 mm, 4 μm column with a flow rate of 1.0 mL min-1, 215 nm wavelength and 10 μL injection volume with run time of 5 min. The method linearity was proved between 5.02-40.17 μg mL-1 and obtained correlation-coefficient value is 1.0000. The mean recovery of roflumilast was 100.6%. The stability indicating nature was established and performed the validation by considerin...
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Asian Journal of Chemistry, 2018
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Asian Journal of Pharmaceutical and Clinical Research, 2019
Objective: The objective of the study was to develop a simple, validated, and affordable visible ... more Objective: The objective of the study was to develop a simple, validated, and affordable visible spectrophotometric method for determination of piperacillin (PIP) present in bulk and powder for injection formulation. Methods: In the present method, cobalt thiocyanate (CTC) was used as a chromogenic reagent where it forms 2:1 ion pair complex at pH 2 with PIP which is having secondary and tertiary amine groups. Results: The formed bluish-green colored ion pair between PIP and CTC is quantitatively extractable into nitrobenzene with an absorption maximum of 665 nm. Regression analysis (r=0.9996) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (3–18 μg/mL). Low values of relative standard deviation (<2%) were observed indicating that the proposed method is reproducible, accurate, and precise. Conclusions: As per the existing guidelines of ICH (international council for harmonization of technical requirements for pharmaceuticals ...
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Oriental Journal of Chemistry, 2017
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Letters in Drug Design & Discovery, 2017
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Polish Journal of Chemical Technology, 2016
Three novel and distinct agricultural waste materials, viz., Casuarinas fruit powder (CFP), sorgh... more Three novel and distinct agricultural waste materials, viz., Casuarinas fruit powder (CFP), sorghum stem powder (SSP) and banana stem powder (BSP) were used as low cost adsorbents for the removal of toxic copper(II) from aqueous solutions. Acid treated adsorbents were characterized by SEM, EDX and FTIR. Different factors effecting adsorption capacity were analyzed and the efficiency order was BSP>SSP>CFP. Based on the extent of compatibility to Freundlich/Langmuir/D-R/Temkin adsorption isotherm and different models (pseudo-first and second order, Boyd, Weber’s and Elovich), chemisorption primarily involved in the case of CFP and SSP, whereas, simultaneous occurrence of chemisorption and physisorption was proposed in the case of BSP. Based on the observations, it was proposed that three kinetic stages involve in adsorption process viz., diffusion of sorbate to sorbent, intra particle diffusion and then establishment of equilibrium. These adsorbents have promising role towards r...
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Synthetic Communications, 2016
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Pharmaceutica Analytica Acta, 2016
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Korean Journal of Chemical Engineering, 2016
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Russian Journal of Physical Chemistry A, 2016
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Russian Journal of Physical Chemistry A, 2016
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Separation Science and Technology, 2016
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Papers by Ratnakaram Venkata Nadh