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    Ery Thro Poiesis

    Transféré par

    polygone
    hematology

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    © All Rights Reserved
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    Ery Thro Poiesis

    Transféré par

    polygone
    16 vues1 page
    hematology

    Copyright

    © © All Rights Reserved

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    PDF ou lisez en ligne sur Scribd

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    hematology

    Droits d'auteur :

    © All Rights Reserved
    Téléchargez comme PDF ou lisez en ligne sur Scribd
    Télécharger au format pdf
    16 vues1 page

    Ery Thro Poiesis

    Transféré par

    polygone
    hematology

    Droits d'auteur :

    © All Rights Reserved
    Téléchargez comme PDF ou lisez en ligne sur Scribd
    Télécharger au format pdf
    sur 1
    Mechanisms in Hematology: Erythropoiesis Regulation of Erythropoiesis Erythropoietin (EPO), a 35 kD glycoprotein, is the primary humoral regulator of erythropoiesis ~ promoting both proliferation and survival of erythroid precursors. Approximately 90% of EPO is synthesized in renal peritubular interstitial cells that respond to an Or-sensing mechanism. As in other cells, the oxygen sensor in renal cells probably is a ferrous iron prolyl hydroxylase that requires molecular O2 as a cosubstrate. It hydroxylates specific proline residue(s) in the hypoxia inducible factor (HIF), a transcription factor that targets a number of erythropoietic genes, including erythropoietin, transferrin, the transferrin receptor (TR), and the vascular-endothelial growth factor (VEGF). When HIF binds to the hypoxia-response element (HRE) on the EPO gene, enhanced transcription results in increased EPO synthesis. In response to a hypoxic stimulus, recruitment of additional EPO-producing peritubular cells supplements the cells that constitutively synthesize EPO; when the hypoxic stimulus is removed, the recruited cells return to their non-secretory state. - TR glycolysis angiogenesis VEGF oxygen s sensor HIF hypoxia EPO WOO gene ONION, EPO Control of erythropoietin synthesis

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