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Published online 2022 Mar 25. doi: 10.1007/s00277-022-04817-8

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Table 3

Multivariate analysis of outcomes

Factors	TRM		OS		DFS
Factors	Univariate	Multivariate (P (HR, 95% CI))	Univariate	Multivariate (P (HR, 95% CI))	Univariate	Multivariate (P (HR, 95% CI))
Gender
Female	0.652	-	0.659	-	0.463	-
Male	0.652	-	0.659	-	0.463	-
Patient age, years
<32	0.831	-	0.545	-	0.831	-
≥32	0.831	-	0.545	-	0.831	-
Donor gender
Female	0.002	0.100 (2.09, 0.87–5.05)	0.015	0.061 (1.87, 0.97–3.58)	0.226	-
Male	0.002	0.100 (2.09, 0.87–5.05)	0.015	0.061 (1.87, 0.97–3.58)	0.226	-
Genetics
Poor-risk	0.071	0.242 (1.30, 0.84–2.00)	0.003	0.007 (1.62, 1.14–2.31)	0.005	0.002 (1.57, 1.18–2.10)
Others	0.071	0.242 (1.30, 0.84–2.00)	0.003	0.007 (1.62, 1.14–2.31)	0.005	0.002 (1.57, 1.18–2.10)
Disease status
Non-CR	0.138	0.439 (1.40, 0.59–3.32)	0.001	0.048 (1.84, 1.00–3.38)	<.001	0.003 (2.23, 1.31–3.81)
CR	0.138	0.439 (1.40, 0.59–3.32)	0.001	0.048 (1.84, 1.00–3.38)	<.001	0.003 (2.23, 1.31–3.81)
HLA mismatched
4–5	0.216	-	0.019	0.315 (1.17, 0.86–1.61)	0.080	0.495 (1.10, 0.84–1.44)
2–3
0–1
Graft source
PBSC	0.383	-	0.303	-	0.555	-
BM+PBSC	0.383	-	0.303	-	0.555	-
Conditioning
Standard	0.002	0.236 (1.64, 0.72–3.69)	0.008	0.841 (1.06, 0.58–1.94)	0.069	0.679 (1.13, 0.65–1.96)
Intensified	0.002	0.236 (1.64, 0.72–3.69)	0.008	0.841 (1.06, 0.58–1.94)	0.069	0.679 (1.13, 0.65–1.96)
Blood stream infection	0.015	0.315 (1.59, 0.64–3.94)	0.282	-	0.309	-
β-lactam	0.009	0.484 (1.86, 0.33–10.59)	0.098	0.468 (1.53, 0.48–4.87)	0.054	0.774 (1.18, 0.39–3.56)
Carbapenems	0.106	0.533 (1.53, 0.40–5.81)	0.191	0.561 (1.36, 0.48–3.85)	0.097	0.429 (1.49, 0.55–4.04)
Piperacillin/tazobactam	0.113	0.830 (1.10, 0.45–2.73)	0.136	0.615 (1.20, 0.60–2.40)	0.302	-
Cephalosporin	0.097	0.613 (1.42, 0.37–5.49)	0.490	-	0.153	0.818 (1.10, 0.48–2.55)
Vancomycin (i.v.)	0.480	-	0.936	-	0.883	-
Amikacin	0.232	-	0.851	-	0.643	-
III-IV aGVHD	<.001	<.001 (7.60, 3.43–16.83)	<.001	<.001 (4.95, 2.60–9.42)	<.001	<.001 (3.12, 1.74–5.60)
AIM score*
High (4–5)	<.001	.003 (3.92, 1.57–9.79)	<.001	<.001 (5.68, 2.75–11.71)	<.001	<.001 (3.04, 1.74–5.31)
Low (0–3)	<.001	.003 (3.92, 1.57–9.79)	<.001	<.001 (5.68, 2.75–11.71)	<.001	<.001 (3.04, 1.74–5.31)

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aGVHD, acute graft-versus-host disease; AIM score, accumulated intestinal microbiota score; BM, bone marrow; CI, confidence interval; CR, complete remission; DFS, disease-free survival; HR, hazard ratio; i.v., intravenous; OS, overall survival; PBSC, peripheral blood stem cell; TRM, transplant-related mortality