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Figure 7

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Schematic diagram illustrating the proposed signaling pathway involved in thrombin-induced COX-2 expression and PGE2 secretion in HTSMCs. Thrombin-induced COX-2 expression associated with PGE2 generation was mediated through PAR1/Gq or Gi/o/PKCα/MAPK-dependent NF-κB activation in HTSMCs.

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