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Figure 2.

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Enhancement of autophagy by rapamycin (Rapa) ameliorates renal interstitial fibrosis in C57BL/6 mice. (A) Immunoblot analyses of LC3, SQSTM1/p62, and COL1 in the obstructed kidneys in different groups as indicated. (B) Quantitative determination of the relative abundance of the indicated proteins among different groups. Data are means ± SEM (n = 6); *, P < 0.001 vs. sham; #, P < 0.05 vs. UUO mice treated with vehicle. (C) Coimmunostaining of LTL (green) and SQSTM1/p62 (red) in kidney sections. Scale bar: 20 μm. (D) Semiquantitative analysis of tubular damage in the obstructed kidneys. Data are means ±SEM (n = 6); *, P < 0.05 vs. sham; #, P < 0.05 vs. UUO mice treated with vehicle. (E) Representative micrographs from indicated groups with either periodic acid-Schiff (PAS; upper panels) or Masson's trichrome staining (lower panels). Scale bar: 20 μm.

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