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Figure 5
BCL-2 family protein subcellular localization in non-apoptotic cells BCL-2 family proteins reported at each location are listed in the corresponding box. Uncertainty or data for which there are conflicting reports are indicated by a ‘?’. Localization that changes during apoptosis is summarized in and . Interactions at the mitochondria are shown in the enlargement top left. Interactions at the mitochondrial associated membrane (MAM), a subdomain of the endoplasmic reticulum in close contact with mitochondria are enlarged below left. Among other proteins, mitofusin proteins (shown as dimer linking the two membranes) bring a specialized subdomain of ER membranes in contact with the mitochondrial outer membrane forming the MAM
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