Fig. 5.

Reduced glucose-induced insulin release leads to a disturbed glucose tolerance in Trpm5^−/− mice. (A) Insulin secretion from WT and Trpm5^−/− islets. Islets were challenged with different glucose concentrations as indicated (n = 8 per group). Insulin release was normalized to islet insulin content. *P < 0.05. (B) Plasma insulin levels after an i.p. glucose injection in overnight fasted WT and Trpm5^−/− mice (n = 4–5 mice; *P < 0.05; **P < 0.01). (C) OGTT and IPGTT glucose tolerance tests in WT and Trpm5^−/− mice. (n = 7 WT and n = 7 Trpm5^−/− mice for OGTT, n = 4 WT and n = 4 Trpm5^−/− mice for IPGTT. *P < 0.05; **P < 0.01.)