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PMC full text:
Circ Res. Author manuscript; available in PMC 2009 Nov 21.
Published in final edited form as:
Circ Res. 2008 Nov 21; 103(11): 1204–1219.
doi: 10.1161/CIRCRESAHA.108.176826

Figure 5

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Mechanisms involved in cardiac regeneration

Potentially, ASCs may lead to cardiac regeneration via different mechanisms. Transdifferentiation into newly formed cardiomyocytes has been the first proposed way. Cell fusion of stem cells with native cardiomyocytes represents a second possibility but the biological meaning of this event remains unclear. Finally, soluble paracrine factors released by the stem cells may induce activation, migration and differentiation of CSCs and/or enhance proliferation of resident cardiomyocytes.

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