This study investigates the effect of shale creep on the stress evolution of a generic nuclear waste repository. Thermohydromechanically (THM) coupled simulations were carried out with the TOUGH-FLAC simulator to model temperature/pore pressure/stress changes due to the decay heating from nuclear waste. The Norton-Bailey creep model, which was calibrated against published creep experiments on shale, was used to simulate different creep properties of shale (i.e., no creep vs. creep). Results show that shale without creep generated and maintained high stress concentrations (~40 MPa) near the disposal tunnel for an extremely long period (~10, 000 years), whereas shale with creep dissipated the stress concentrations and developed uniform and isotropic stress field of roughly 12 MPa (in compression), which corresponded with the overburden stress level at the tunnel depth, by as early as 100 years since the emplacement of nuclear waste. Also, it was found that shale with creep increased compressive stresses in the bentonite backfill compared to shale without creep by as much as 130% at 10, 000 years due to creep-induced tunnel volume reduction.

We have investigated the function of the synaptic vesicle protein Rabphilin-3A in neurotransmitter release at the squid giant synapse. Presynaptic microinjection of recombinant Rabphilin-3A reversibly inhibited the exocytotic release of neurotransmitter. Injection of fragments of Rabphilin-3A indicate that at least two distinct regions of the protein inhibit neurotransmitter release: the NH2-terminal region that binds Rab3A and is phosphorylated by protein kinases and the two C2 domains that interact with calcium, phospholipid, and beta-adducin. Each of the inhibitory fragments and the full-length protein had separate effects on presynaptic morphology, suggesting that individual domains were inhibiting a subset of the reactions in which the full-length protein participates. In addition to inhibiting exocytosis, constructs containing the NH2 terminus of Rabphilin-3A also perturbed the endocytotic pathway, as indicated by changes in the membrane areas of endosomes, coated vesicles, and the plasma membrane. These results indicate that Rabphilin-3A regulates synaptic vesicle traffic and appears to do so at distinct stages of both the exocytotic and endocytotic pathways.

© 2016 The Author(s).Background: The proportion of registered nurses (RNs) with employment in health-related positions before their initial RN education has increased in the past two decades. Previous research found that prior health-related employment is

We report an extensive search for Lyα emitters (LAEs) at z = 6.5 in the Subaru Deep Field. Subsequent spectroscopy with Subaru and Keck identified eight more LAEs, giving a total of 17 spectroscopically confirmed LAEs at z = 6.5. Based on this spectroscopic sample of 17, complemented by a photometric sample of 58 LAEs, we have derived a more accurate Lyα luminosity function of LAEs at z = 6.5, which reveals an apparent deficit at the bright end of ∼0.75 mag fainter L*, compared with that observed at z = 5.7. The difference in the LAE luminosity functions between z = 5.7 and 6.5 is significant at the 3 σ level, which is reduced to 2 σ when cosmic variance is taken into account. This result may imply that the reionization of the universe has not been completed at z = 6.5. We found that the spatial distribution of LAEs at z = 6.5 was homogeneous over the field. We discuss the implications of these results for the reionization of the universe. © 2006. The American Astronomical Society. All rights reserved.

Background

Geant4 is a Monte Carlo code extensively used in medical physics for a wide range of applications, such as dosimetry, micro- and nanodosimetry, imaging, radiation protection, and nuclear medicine. Geant4 is continuously evolving, so it is crucial to have a system that benchmarks this Monte Carlo code for medical physics against reference data and to perform regression testing.

Aims

To respond to these needs, we developed G4-Med, a benchmarking and regression testing system of Geant4 for medical physics.

Materials and methods

G4-Med currently includes 18 tests. They range from the benchmarking of fundamental physics quantities to the testing of Monte Carlo simulation setups typical of medical physics applications. Both electromagnetic and hadronic physics processes and models within the prebuilt Geant4 physics lists are tested. The tests included in G4-Med are executed on the CERN computing infrastructure via the use of the geant-val web application, developed at CERN for Geant4 testing. The physical observables can be compared to reference data for benchmarking and to results of previous Geant4 versions for regression testing purposes.

Results

This paper describes the tests included in G4-Med and shows the results derived from the benchmarking of Geant4 10.5 against reference data.

Discussion

Our results indicate that the Geant4 electromagnetic physics constructor G4EmStandardPhysics_option4 gives a good agreement with the reference data for all the tests. The QGSP_BIC_HP physics list provided an overall adequate description of the physics involved in hadron therapy, including proton and carbon ion therapy. New tests should be included in the next stage of the project to extend the benchmarking to other physical quantities and application scenarios of interest for medical physics.

Conclusion

The results presented and discussed in this paper will aid users in tailoring physics lists to their particular application.