Methamnetamine

Methamnetamine
Legal status
Legal status	DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act; Illegal in Japan;
Identifiers
	IUPAC name N-Methyl-1-(naphthalen-2-yl)propan-2-amine;
CAS Number	1178720-66-5 ;
PubChem CID	17802040;
ChemSpider	38754167;
UNII	CAS64BB01B;
CompTox Dashboard (EPA)	DTXSID801032850 ;
Chemical and physical data
Formula	C14H17N
Molar mass	199.297 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNC(C)Cc1ccc2ccccc2c1;
	InChI InChI=1S/C14H17N/c1-11(15-2)9-12-7-8-13-5-3-4-6-14(13)10-12/h3-8,10-11,15H,9H2,1-2H3; Key:BWWWOLYZMKACSB-UHFFFAOYSA-N;

Methamnetamine (also known as methylnaphetamine, MNA, MNT and PAL-1046) is a triple monoamine releasing agent and N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine.^[1]^[2]^[3] It has been sold online as a designer drug.^[4]^[5]

It acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC₅₀ values of 13 nM, 34 nM, and 10 nM, respectively.^[1]

Legal status

Methamnetamine is illegal in Japan.^[6]

^ ^a ^b Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE (April 2012). "Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters". The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251–262. doi:10.1124/jpet.111.188946. PMC 3364510. PMID 22271821.
^ Youn DH, Kim JM, Hong YK, Park SI, Lee JM, Kim YH, et al. (August 2021). "Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study". Psychopharmacology. 238 (8): 2155–2165. doi:10.1007/s00213-021-05840-9. PMID 33811503. S2CID 232773019.
^ Hong YK, Kim YH, Lee JM, Yoo HH, Choi SO, Kang MS (July 2021). "Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry". International Journal of Legal Medicine. 135 (4): 1471–1476. doi:10.1007/s00414-021-02594-z. PMID 33928430. S2CID 233451101.
^ "Methamnetamine". WEDINOS.
^ "Methamnetamine". New Synthetic Drugs Database. 9 November 2023.
^ "指定薬物名称・構造式一覧（平成27年9月16日現在）" [List of designated drug names and structural formulas (as of September 16, 2015)] (PDF). 厚生労働省 [Ministry of Health, Labour and Welfare] (in Japanese). 16 September 2015. Retrieved 8 October 2015.

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