CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5.[1]
| CD72 molecule | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CD72 | ||||||
| NCBI gene | 971 | ||||||
| HGNC | 1696 | ||||||
| OMIM | 107272 | ||||||
| RefSeq | NM_001782 | ||||||
| UniProt | P21854 | ||||||
| Other data | |||||||
| Locus | Chr. 9 p | ||||||
| |||||||
CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.[2]
See also
editReferences
edit- ^ Abbas AK, Licktman A (2003). Cellular and Molecular Immunology (5th ed.). Saunders. p. 512. ISBN 978-0-7216-0008-6.
- ^ Parnes JR, Pan C (August 2000). "CD72, a negative regulator of B-cell responsiveness". Immunological Reviews. 176 (1): 75–85. doi:10.1034/j.1600-065x.2000.00608.x. PMID 11043769. S2CID 29775275.
External links
edit- Dr. Jane Parnes lab Archived 2007-03-10 at the Wayback Machine at Stanford University
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