The song was first heard when Travis Scott performed it live at JMBLYA.[1] It was later released on June 21, 2015. "Antidote" was not initially intended to appear on Rodeo, as confirmed on Scott's SoundCloud on June 23, 2015: "This is for the real fans; the real ragers! This is some vibes for the summer. This isn’t on Rodeo… it’s coming soon." However, due to the song's popularity, Scott included the track on his debut album. On July 29, 2015, "Antidote" was released via digital distribution as the album's second single. The song samples "All I Need" by Lee Fields and The Expressions.
On September 3, 2015, a teaser for the "Antidote" music video was uploaded on Scott's Vevo channel.[2] The video premiered on September 18, 2015.[3] The music video features Dominican models Yaris Sanchez and Ayisha Diaz and rapper Rich Hil (with green hair).
On September 23, 2015, Travis Scott performed "Antidote", live on national television, on Jimmy Kimmel Live.[4][5] On November 17, 2015, in between dates on The Weeknd's "Madness Fall Tour," Travis Scott appeared on Late Night with Seth Meyers, where he performed a medley of "Antidote" and "Pray 4 Love".[6][7]