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Emily Bernstein

Emily Bernstein is a professor at Mount Sinai School of Medicine known for her research on RNA interference, epigenetics, and cancer, especially melanoma.

Emily Bernstein
Alma materState University of New York at Stony Brook
Scientific career
InstitutionsMount Sinai College of Medicine
ThesisDicer, a novel RNase III, is required for RNA interference and development (2003)
Doctoral advisorGregory Hannon

Education and career

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Bernstein received her B.S. from McGill University in 1998 and earned a Ph.D. from Stony Brook University in 2003.[1] Following her Ph.D. she was a postdoctoral researcher at Rockefeller University where she worked with David Allis.[2] In 2008 she moved to Mount Sinai School of Medicine where, as of 2022, she is a professor in the department of oncology and dermatology.[3]

Research

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Bernstein is known for her research on RNA interference, epigenetics, and cell development. Her early research examined the enzyme Dicer, its role in cell development in mice,[4] and RNA interference.[5] While a postdoctoral researcher she examined linkages between non-coding RNA and chromatin[6][7] and DNA methylation.[8] Subsequently, she has worked on histones,[9][10] gene silencing,[11] and tumor cell development.[12][13] In 2022 her team discovered alterations to a gene which can lead to melanoma.[14][15]

Selected publications

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  • Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. S2CID 4371481.
  • Hammond, Scott M.; Bernstein, Emily; Beach, David; Hannon, Gregory J. (2000). "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells". Nature. 404 (6775): 293–296. Bibcode:2000Natur.404..293H. doi:10.1038/35005107. ISSN 0028-0836. PMID 10749213. S2CID 9091863.
  • Goldberg, Aaron D.; Allis, C. David; Bernstein, Emily (2007-02-23). "Epigenetics: A Landscape Takes Shape". Cell. 128 (4): 635–638. doi:10.1016/j.cell.2007.02.006. ISSN 0092-8674. PMID 17320500. S2CID 16604496.
  • Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J; Anderson, Kathryn V; Hannon, Gregory J (2003-11-01). "Dicer is essential for mouse development". Nature Genetics. 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. S2CID 972721.

Awards and honors

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In 2014 Bernstein received a young investigators award from the Pershing Square Foundation.[16]

References

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  1. ^ "Speakers". 2022-05-15. Archived from the original on 15 May 2022. Retrieved 2022-05-15.
  2. ^ "Investigator | Bernstein Laboratory". Bernstein Laboratory |. 2015-04-16. Retrieved 2022-05-15.
  3. ^ "Emily Bernstein | Mount Sinai - New York". Mount Sinai Health System. Retrieved 2022-05-15.
  4. ^ Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J; Anderson, Kathryn V; Hannon, Gregory J (2003-11-01). "Dicer is essential for mouse development". Nature Genetics. 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. S2CID 972721.
  5. ^ Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. S2CID 4371481.
  6. ^ Bernstein, Emily; Allis, C. David (2005-07-15). "RNA meets chromatin". Genes & Development. 19 (14): 1635–1655. doi:10.1101/gad.1324305. ISSN 0890-9369. PMID 16024654.
  7. ^ Bernstein, Emily; Duncan, Elizabeth M.; Masui, Osamu; Gil, Jesus; Heard, Edith; Allis, C. David (2006). "Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin". Molecular and Cellular Biology. 26 (7): 2560–2569. doi:10.1128/MCB.26.7.2560-2569.2006. ISSN 0270-7306. PMC 1430336. PMID 16537902.
  8. ^ Ooi, Steen K. T.; Qiu, Chen; Bernstein, Emily; Li, Keqin; Jia, Da; Yang, Zhe; Erdjument-Bromage, Hediye; Tempst, Paul; Lin, Shau-Ping; Allis, C. David; Cheng, Xiaodong (2007). "DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA". Nature. 448 (7154): 714–717. Bibcode:2007Natur.448..714O. doi:10.1038/nature05987. ISSN 0028-0836. PMC 2650820. PMID 17687327.
  9. ^ Gaspar-Maia, Alexandre; Qadeer, Zulekha A.; Hasson, Dan; Ratnakumar, Kajan; Adrian Leu, N.; Leroy, Gary; Liu, Shichong; Costanzi, Carl; Valle-Garcia, David; Schaniel, Christoph; Lemischka, Ihor (2013-06-26). "MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency". Nature Communications. 4 (1): 1565. Bibcode:2013NatCo...4.1565G. doi:10.1038/ncomms2582. ISSN 2041-1723. PMC 4055026. PMID 23463008.
  10. ^ Vardabasso, Chiara; Hasson, Dan; Ratnakumar, Kajan; Chung, Chi-Yeh; Duarte, Luis F.; Bernstein, Emily (2014). "Histone variants: emerging players in cancer biology". Cellular and Molecular Life Sciences. 71 (3): 379–404. doi:10.1007/s00018-013-1343-z. ISSN 1420-682X. PMC 4025945. PMID 23652611.
  11. ^ Chicas, Agustin; Kapoor, Avnish; Wang, Xiaowo; Aksoy, Ozlem; Evertts, Adam G.; Zhang, Michael Q.; Garcia, Benjamin A.; Bernstein, Emily; Lowe, Scott W. (2012-06-05). "H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence". Proceedings of the National Academy of Sciences. 109 (23): 8971–8976. Bibcode:2012PNAS..109.8971C. doi:10.1073/pnas.1119836109. ISSN 0027-8424. PMC 3384172. PMID 22615382.
  12. ^ Sosa, Maria Soledad; Parikh, Falguni; Maia, Alexandre Gaspar; Estrada, Yeriel; Bosch, Almudena; Bragado, Paloma; Ekpin, Esther; George, Ajish; Zheng, Yang; Lam, Hung-Ming; Morrissey, Colm (2015). "NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes". Nature Communications. 6 (1): 6170. Bibcode:2015NatCo...6.6170S. doi:10.1038/ncomms7170. ISSN 2041-1723. PMC 4313575. PMID 25636082.
  13. ^ Strub, Thomas; Ghiraldini, Flavia G.; Carcamo, Saul; Li, Man; Wroblewska, Aleksandra; Singh, Rajendra; Goldberg, Matthew S.; Hasson, Dan; Wang, Zichen; Gallagher, Stuart J.; Hersey, Peter (2018). "SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling". Nature Communications. 9 (1): 3440. Bibcode:2018NatCo...9.3440S. doi:10.1038/s41467-018-05966-z. ISSN 2041-1723. PMC 6109055. PMID 30143629.
  14. ^ "Scientists discover gene mutation that signals aggressive melanoma". ScienceDaily. April 6, 2022. Retrieved 2022-05-15.
  15. ^ Carcamo, Saul; Nguyen, Christie B.; Grossi, Elena; Filipescu, Dan; Alpsoy, Aktan; Dhiman, Alisha; Sun, Dan; Narang, Sonali; Imig, Jochen; Martin, Tiphaine C.; Parsons, Ramon (2022-04-05). "Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma". Cell Reports. 39 (1): 110637. doi:10.1016/j.celrep.2022.110637. ISSN 2211-1247. PMC 9013128. PMID 35385731.
  16. ^ Benson, Barbara (May 5, 2014). "Wall Street funds cancer-research up-and-comers". Crain's New York Business; New York. Vol. 30, no. 18. p. 22 – via ProQuest.
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