S-14,506

S-14,506
Names
	Preferred IUPAC name 4-Fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide
Identifiers
CAS Number	135722-25-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:64101;
ChemSpider	116528;
IUPHAR/BPS	24;
PubChem CID	131906;
UNII	YVO8LE53MI ;
CompTox Dashboard (EPA)	DTXSID9043986 ;
	InChI InChI=1S/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29) Key: IFMQODYDAUKKEN-UHFFFAOYSA-N; InChI=1/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29) Key: IFMQODYDAUKKEN-UHFFFAOYAH;
	SMILES COC1=CC2=C(C=CC=C2N3CCN(CC3)CCNC(=O)C4=CC=C(C=C4)F)C=C1;
Properties
Chemical formula	C24H26FN3O2
Molar mass	407.489 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

S-14,506 is a naphthylpiperazine, a 5-HT1A receptor agonist,^[1] and a dopamine receptor antagonist.^[2]

References

^ Milligan, G.; Kellett, E.; Dacquet, C.; Dubreuil, V.; Jacoby, E.; Millan, M. J.; Lavielle, G.; Spedding, M. (2001). "S 14506: Novel receptor coupling at 5-HT(1A) receptors". Neuropharmacology. 40 (3): 334–344. doi:10.1016/s0028-3908(00)00162-3. PMID 11166326. S2CID 36060096.
^ Protais, P.; Chagraoui, A.; Arbaoui, J.; Mocaër, E. (1994). "Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents". European Journal of Pharmacology. 271 (1): 167–177. doi:10.1016/0014-2999(94)90277-1. PMID 7698199.

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