Choline transporter-like protein 2

SLC44A2
Identifiers
Aliases	SLC44A2, CTL2, PP1292, solute carrier family 44 member 2
External IDs	OMIM: 606106; MGI: 1915932; HomoloGene: 10711; GeneCards: SLC44A2; OMA:SLC44A2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,644,557 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,266,324 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; right lung; ; right testis; ; left testis; ; spleen; ; right coronary artery; ; popliteal artery; ; granulocyte; ; tibial arteries; ; upper lobe of left lung;
	Top expressed in
	vestibular membrane of cochlear duct; ; gastrula; ; decidua; ; aortic valve; ; ascending aorta; ; left lung lobe; ; right lung lobe; ; stria vascularis; ; transitional epithelium of urinary bladder; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	choline transmembrane transporter activity; signal transducer activity;
Cellular component	integral component of membrane; lysosomal membrane; plasma membrane; extracellular exosome; membrane; specific granule membrane;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; phosphatidylcholine biosynthetic process; choline transport; transmembrane transport; signal transduction; neutrophil degranulation; transport;
	Sources:Amigo / QuickGO
Orthologs
	57153
	68682
	ENSG00000129353
	ENSMUSG00000057193
	Q8IWA5
	Q8BY89
	NM_001145056; NM_020428; NM_001363611
	NM_001199186; NM_152808; NM_001359227
	NP_001138528; NP_065161; NP_001350540
	NP_001186115; NP_690021; NP_001346156
	Wikidata
View/Edit Human	View/Edit Mouse

Choline transporter-like protein 2 is a protein that in humans is encoded by the SLC44A2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129353 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proc Natl Acad Sci U S A. 97 (4): 1835–40. Bibcode:2000PNAS...97.1835O. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.
^ Traiffort E, Ruat M, O'Regan S, Meunier FM (Feb 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". J Neurochem. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662. S2CID 30921826.
^ "Entrez Gene: SLC44A2 solute carrier family 44, member 2".

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nair TS, Kozma KE, Hoefling NL, et al. (2004). "Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss". J. Neurosci. 24 (7): 1772–9. doi:10.1523/JNEUROSCI.5063-03.2004. PMC 6730453. PMID 14973250.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129353 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057193 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10677542-5] O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proc Natl Acad Sci U S A. 97 (4): 1835–40. Bibcode:2000PNAS...97.1835O. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.

[pmid15715662-6] Traiffort E, Ruat M, O'Regan S, Meunier FM (Feb 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". J Neurochem. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662. S2CID 30921826.

[entrez-7] "Entrez Gene: SLC44A2 solute carrier family 44, member 2".

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Choline transporter-like protein 2

See also

References

Further reading