Naphthoylindoles

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Naphthoylindoles are a class of synthetic cannabinoids.^[1]

Behaving similarly in vivo to endocannabinoids such as anandamide or 2-arachidonoylglycerol (2-AG), Naphthoylindoles can bind to endocannabinoid receptors in animals, presenting as CB₁ and/or CB₂ partial/full agonists.

They have gained notoriety over the years for illicit usage and distribution in Europe and North America, typically marketed as "herbal incense blends."^[2]

• Structural scheduling of synthetic cannabinoids
• List of JWH cannabinoids, includes many naphthoylindoles
• Naphthoyl, an acyl group, derived, in this case, from 1-naphthoic acid
• Indole