KCNJ9

KCNJ9
Identifiers
Aliases	KCNJ9, GIRK3, KIR3.3, potassium voltage-gated channel subfamily J member 9, potassium inwardly rectifying channel subfamily J member 9
External IDs	OMIM: 600932; MGI: 108007; HomoloGene: 37989; GeneCards: KCNJ9; OMA:KCNJ9 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,090,563 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,156,885 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; primary visual cortex; ; right hemisphere of cerebellum; ; right frontal lobe; ; lateral nuclear group of thalamus; ; dorsolateral prefrontal cortex; ; superior frontal gyrus; ; prefrontal cortex; ; postcentral gyrus;
	Top expressed in
	cerebellar vermis; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; lobe of cerebellum; ; neural layer of retina; ; medial geniculate nucleus; ; cingulate gyrus; ; primary motor cortex; ; perirhinal cortex; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; inward rectifier potassium channel activity; voltage-gated ion channel activity; G-protein activated inward rectifier potassium channel activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; parallel fiber to Purkinje cell synapse; integral component of presynaptic membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3765
	16524
	ENSG00000162728
	ENSMUSG00000038026
	Q92806
	P48543
	NM_004983
	NM_008429; NM_001360808
	NP_004974
	NP_032455; NP_001347737
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.^[5]^[6]^[7]

Function

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex.^[7]

Interactions

KCNJ9 has been shown to interact with KCNJ6.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162728 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038026 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG (Oct 1995). "Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23". Genomics. 29 (3): 808–9. doi:10.1006/geno.1995.9928. PMID 8575783.
^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
^ ^a ^b "Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9".
^ Jelacic TM, Kennedy ME, Wickman K, Clapham DE (Nov 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". The Journal of Biological Chemistry. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667.
^ Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (Nov 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.

External links

KCNJ9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162728 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038026 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8575783-5] Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG (Oct 1995). "Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23". Genomics. 29 (3): 808–9. doi:10.1006/geno.1995.9928. PMID 8575783.

[pmid16382105-6] Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.

[entrez-7] "Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9".

[pmid10956667-8] Jelacic TM, Kennedy ME, Wickman K, Clapham DE (Nov 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". The Journal of Biological Chemistry. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667.

[pmid12297500-9] Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (Nov 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.

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KCNJ9

Function

Interactions

See also

References

Further reading

External links