FG-7142

FG-7142
Names
	Preferred IUPAC name N-Methyl-5H-pyrido[3,4-b]indole-2-carboxamide
	Other names ZK-31906
Identifiers
CAS Number	78538-74-6 ;
3D model (JSmol)	Interactive image;
ChemSpider	4222 ;
MeSH	C526324
PubChem CID	4375;
UNII	60PO70N1BP ;
CompTox Dashboard (EPA)	DTXSID30999832 ;
	InChI InChI=1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17) Key: QMCOPDWHWYSJSA-UHFFFAOYSA-N ;
	SMILES CNC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2;
Properties
Chemical formula	C13H11N3O
Molar mass	225.24594
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

FG-7142 (ZK-31906) is a drug which acts as a partial inverse agonist at the benzodiazepine allosteric site of the GABA_A receptor.^[1] It has anorectic,^[2] anxiogenic and pro-convulsant effects.^[3] It also increases release of acetylcholine and noradrenaline,^[4] and improves memory retention in animal studies.^[5]

References

^ Stevenson CW, Halliday DM, Marsden CA, Mason R (2007). "Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions". Synapse. 61 (8): 646–63. CiteSeerX 10.1.1.323.5370. doi:10.1002/syn.20414. PMID 17503486. S2CID 13415418.
^ Cottone P, Sabino V, Steardo L, Zorrilla EP (May 2007). "FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability". Neuropsychopharmacology. 32 (5): 1069–81. doi:10.1038/sj.npp.1301229. PMID 17077811.
^ Evans AK, Lowry CA (Winter 2007). "Pharmacology of the β-carboline FG-7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA_A receptor: neurochemical, neurophysiological, and behavioral effects". CNS Drug Reviews. 13 (4): 475–501. doi:10.1111/j.1527-3458.2007.00025.x. PMC 6494137. PMID 18078430.
^ Claustre Y, Rouquier L, Desvignes C, Leonetti M, Montégut J, Aubin N, Allouard N, Bougault I, Oury-Donat F, Steinberg R (2006). "Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat". Neuroscience. 141 (3): 1481–8. doi:10.1016/j.neuroscience.2006.05.006. PMID 16781820. S2CID 24944657.
^ McNally GP, Augustyn KA, Richardson R (2008). "GABA_A receptors determine the temporal dynamics of memory retention". Learning and Memory. 15 (3): 106–11. doi:10.1101/lm.806008. PMC 2275652. PMID 18285469.

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[pmid17503486-1] Stevenson CW, Halliday DM, Marsden CA, Mason R (2007). "Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions". Synapse. 61 (8): 646–63. CiteSeerX 10.1.1.323.5370. doi:10.1002/syn.20414. PMID 17503486. S2CID 13415418.

[2] Cottone P, Sabino V, Steardo L, Zorrilla EP (May 2007). "FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability". Neuropsychopharmacology. 32 (5): 1069–81. doi:10.1038/sj.npp.1301229. PMID 17077811.

[3] Evans AK, Lowry CA (Winter 2007). "Pharmacology of the β-carboline FG-7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA_A receptor: neurochemical, neurophysiological, and behavioral effects". CNS Drug Reviews. 13 (4): 475–501. doi:10.1111/j.1527-3458.2007.00025.x. PMC 6494137. PMID 18078430.

[4] Claustre Y, Rouquier L, Desvignes C, Leonetti M, Montégut J, Aubin N, Allouard N, Bougault I, Oury-Donat F, Steinberg R (2006). "Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat". Neuroscience. 141 (3): 1481–8. doi:10.1016/j.neuroscience.2006.05.006. PMID 16781820. S2CID 24944657.

[5] McNally GP, Augustyn KA, Richardson R (2008). "GABA_A receptors determine the temporal dynamics of memory retention". Learning and Memory. 15 (3): 106–11. doi:10.1101/lm.806008. PMC 2275652. PMID 18285469.

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v t e Convulsants
GABA receptor antagonists	Bicuculline Bicyclic phosphates (TBPS, TBPO, IPTBO) BIDN Chlorophenylsilatrane Cicutoxin Cloflubicyne Coriamyrtin Dihydropicrotoxinin DMCM EBOB Endosulfan FG-7142 Fipronil Flurothyl Gabazine Oenanthotoxin Pentylenetetrazol Phenylsilatrane Picrotoxin p-CN-TBOB p-NCS-TBOB RDX TBOB Tetramethylenedisulfotetramine Thujone Trimethylolpropane phosphite Tutin
GABA synthesis inhibitors	3-Mercaptopropionic acid 4-Deoxypyridoxine Allylglycine Crimidine Decaborane Ginkgotoxin Isoniazid Pentaborane Thiocarbohydrazide Toxopyrimidine
Glycine receptor antagonists	Coriamyrtin Dendrobine Picrotoxin Strychnine Tutin
Glutamate receptor agonists	AMPA Domoic acid Kainic acid NMDA Quisqualic acid Tetrazolylglycine
Convulsant barbiturates	CHEB Diberal (DMBB) McN-481
Other	2,2,3,3-Tetrafluoropropyl trifluoromethyl ether Bromocamphor Camphor FAZ-4 Fluoroethyl fluoroacetate MC-2973 Methionine sulfoximine Methyl fluoroacetate Nitrocyclohexane Thebaine