From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene .[ 5] [ 6] [ 7]
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex , where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family.[ 8] meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.[ 7]
AP1B1 has been shown to interact with KIF13A [ 9] AP1G1 .[ 10] [ 11] [ 12]
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