18-Methylaminocoronaridine

18-Methylaminocoronaridine
Identifiers
CAS Number	1807784-35-5 [EPA];
PubChem CID	71308131;
ChemSpider	24721797 ;
CompTox Dashboard (EPA)	DTXSID301046165 ;
Chemical and physical data
Formula	C22H29N3O2
Molar mass	367.493 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c4cccc1c4[nH]c3c1CCN2CC(C5)CC3(C(=O)OC)C2C5CCNC;
	InChI InChI=1S/C22H29N3O2/c1-23-9-7-15-11-14-12-22(21(26)27-2)19-17(8-10-25(13-14)20(15)22)16-5-3-4-6-18(16)24-19/h3-6,14-15,20,23-24H,7-13H2,1-2H3/t14-,15+,20+,22-/m1/s1 ; Key:YKMOJVPLIUXEIP-SVBQBFEESA-N ;
	(verify)

(−)-18-Methylaminocoronaridine (18-MAC) is a second generation synthetic derivative of ibogaine developed by the research team led by the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from the University of Vermont.^[1]^[2]

References

^ Kuehne ME, He L, Jokiel PA, Pace CJ, Fleck MW, Maisonneuve IM, et al. (June 2003). "Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents". Journal of Medicinal Chemistry. 46 (13): 2716–30. doi:10.1021/jm020562o. PMID 12801235.
^ Pace CJ, Glick SD, Maisonneuve IM, He LW, Jokiel PA, Kuehne ME, Fleck MW (May 2004). "Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration". European Journal of Pharmacology. 492 (2–3): 159–67. doi:10.1016/j.ejphar.2004.03.062. PMID 15178360.