Eastern Cuba is a region of Cuba.

• 20.344444-74.4955561 Baracoa
• 20.381667-76.6427782 Bayamo
• 20.138333-75.2061113 Guantanamo
• 20.887222-76.2630564 Holguin
• 20.966667-76.955 Las Tunas
• 20.655556-74.9416676 Moa
• 20.021667-75.8294447 Santiago de Cuba

• 20.540783-75.3911481 Parque Nacional Cayo Saetia. Cayo Saetia is an island that was formed artificially when the Entrecascos peninsula was cut for a channel that's about 100m wide and unites the bays of Levisa and Cabonico. Cayo Saetia conserves its wild environment in an almost virgin state (including beaches and a peaceful lagoon) that offers the unique opportunity to carry out safaris among the forest under a conception of Natural Park. (updated Oct 2015)
• 19.9175-75.162 Guantánamo Bay — access is available only to the northern part; there is no general access to the US Naval Base in the southern part

There are international (Canada, UK) and domestic flights to Holguín's Aeropuerto Internacional Frank País (HOG ^IATA). There are flights from Havana to Santiago de Cuba's Antonio Maceo Airport (SCU ^IATA).

Sunrise Airways flies from Port-au-Prince and Cap-Haitien to SCU, and from Port-au-Prince to HOG (July 2021).

Trains from Havana stop at Guantánamo city, Holguín, Honduras, Manuel Tames, Martires de la Frontera, San Anselmo and Yayal.

Eastern Cuba has several natural UNESCO World Heritage sites:

• Alejandro de Humboldt National Park in the provinces of Holguín and Guantánamo
• The Archaeological Landscape of the First Coffee Plantations in the South-East of Cuba around the mountain range Sierra Maestra
• Desembarco del Granma National Park in Granma province