Talk:Actin

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This article contains a translation of Actina from es.wikipedia.

// This article is full of Spanishisms! Someone, please correct all those "i"s to "y"s! — Preceding unsigned comment added by 108.162.182.14 (talk) 07:04, 9 March 2014 (UTC)[reply]

This article was the subject of a Wiki Education Foundation-supported course assignment, between 23 August 2021 and 10 December 2021. Further details are available on the course page. Student editor(s): Knove001.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 16:50, 17 January 2022 (UTC)[reply]

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): CKelly182.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 13:21, 16 January 2022 (UTC)[reply]

I think actin is worthy of its own article. It can certainly be expanded with more information into a much longer article. The section in cytoskeleton can discuss actin briefly, then link here for more in-depth information. What does everyone else think? — Brim 07:10, Nov 26, 2004 (UTC)

I agree. Just see: "What links here" and compare to microfilaments. Its definately worth its own article, and microfilaments shouldn't be merged with cytoskeleton either. Nina 09:52, 26 Nov 2004 (UTC)

I believe that Actin and microfilaments should be merged. They both talk about the same thing: actin microfilaments. Strictly speaking "actin" refers only to the monomers that make up an actin microfilament. Tycho 18:40, 26 Nov 2004 (UTC)

I think merging actin and microfilaments would be acceptable, with microfilaments being discussed in the Actin article. — Brim 07:01, Nov 27, 2004 (UTC)

Alright - Actin is not a single protein but a whole protein family as so far 6 different actin genes - [ACTA1], [ACTA2], [ACTB], [ACTC], [ACTG1], [ACTG2] - that are active, plus several pseudogenes, have been discovered in humans only (i bet there are many more in the rest of the live world). So, the info about the actin(s) shoud be part of the [actin] section of Cytoskeleton, where its function should be explained and where links to all the members to the family should be given, which i will do, unless someone else has already done it. BorisTM 07:48, 25 October 2005 (UTC)[reply]

"Recent studies have also suggested that actin network on the cell cortex serve as barriers for molecular diffusion within the plasmic membrane." (last line in the article)

If someone could locate and cite these studies, it would be helpful.

actin based motility need to be mentioned in this article. 128.255.106.132 23:03, 11 May 2006 (UTC)[reply]

You are correct vesicle fusion and several processes including adhesion need actin, also the gel-sol state is essential for amoeboid movement. There is no mention of actin treadmilling either. Weak article altogether.GetAgrippa 13:59, 11 October 2006 (UTC)[reply]

"In the first case, one end of myosin is bound to the plasma membrane while the other end walks towards the plus end of the actin filament." Actin attaches to focal adhesions, adherant plaques, membrane specializations not myosin attaching to plasma membrane. Well there are novel myosins and one that apparently attach to vesicles for movement.GetAgrippa 22:16, 10 October 2006 (UTC)[reply]

You might be right. Do you want to edit the article? Please add sources if you have any. Also muscle contraction and contractile bundles are a bit mixed in that subsection. A reader might not get the distinction between the two. --Splette ^Talk 22:20, 10 October 2006 (UTC)[reply]

I am busy with other articles, but the discussion would include actinin,dystrophin,vinculin, and also the intermediate filaments desmin and/or vimentin. GetAgrippa 17:54, 11 October 2006 (UTC)[reply]

"ACTG2 codes for the largest actin isoform, which has nine exons, one of which, the one located at the 5' end, is not translated.[125] It is a γ-actin that is expressed in the enteric smooth muscle. No mutations to this gene have been found that correspond to pathologies, although microarrays have shown that this protein is more often expressed in cases that are resistant to chemotherapy using cisplatin.[145]" -Kia ora, sorry never suggested an edit before but this statement in bold is incorrect, ACTG2 is highly linked with CIPO, particularly the myopathic presentation known as Visceral Smooth Muscle Myopathy 1 (VSCM1; MIM#155310). Here is a paper quoting its high correlation at 44-50% of CIPO cases (the paper meant VSCM1 cases but misquoted the study it reference and said CIPO instead of VSCM1) [1] — Preceding unsigned comment added by 139.80.46.150 (talk) 23:42, 28 September 2022 (UTC)[reply]

Should this section include text to accompany the diagram? I don't think it's self-explanatory, especially to say a high school student. Master gopher (talk) 11:48, 17 June 2009 (UTC)[reply]

Surely there is a case for a fifth function: cell separation during cytokinesis? (the most essential role of all...?). It isn't really part of cell motility, and the actin is specifically created and consumed, rtaher than forming part of the cytoskeleton.Allangmiller (talk) 11:10, 31 May 2010 (UTC)[reply]

Absolutely. It's mentioned briefly in the lead but ought to be listed as a bullet point under functions. Feel free to add. Adrian J. Hunter^{(talk•contribs)} 13:15, 31 May 2010 (UTC)[reply]

Here is a movie from the WikiCommons (C. elegans early embryo) which could be used for this article. It shows:

1) Actin is dynamically moving 2) Its role for cytokinesis (abscission) In the current state, the article is only showing static images, so I think this movie could improve this article. Any comments/suggestions? Ptrrupprecht (talk) 17:00, 29 April 2013 (UTC)[reply]

I definitely like it, though I would caution that it should be embedded within the appropriate-sub-section of the article and that it needs a pretty substantial explanation in the image caption. Without that context, it just looks like some blobs with pretty green speckles and flashes to those of us without a molecular / cell background. HCA (talk) 18:07, 29 April 2013 (UTC)[reply]

Done. --Ptrrupprecht (talk) 18:52, 30 April 2013 (UTC)[reply]

The comment(s) below were originally left at Talk:Actin/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Last edited at 21:08, 18 February 2007 (UTC). Substituted at 06:38, 29 April 2016 (UTC)

I am simply reviewing the Location and Function sub-section for a class I am currently in. Under the section "Muscle Contraction", the outline of muscle contraction has no cited sources. There are two paragraphs in which neither have sources included within them. Also, under the "Nuclear Actin" section, there seems to be a lack of graphics. Perhaps it would be helpful to provide some graphics to help understand the role of actin in the nucleus. The rest of the article seems to have a fair share of visuals to help understand the material, and I think the same would be helpful for this section as well. Overall, the "Location and Function" section seems to be fairly well thought-out and put together. The information overall is strong, and would be a good source for most. CKelly182 (talk) 19:40, 27 September 2016 (UTC) Chris K.[reply]

Hi all, this article seems to have become a bit of a patchwork. I'm hoping to find the time to do some cleanup over the next couple of weeks. As part of that, here are a couple of paragraphs that were in the Structure section but seem a bit broader than "structure". Placing them here temporarily until I find a place to re-home them:

I came here through a link from a page which tries to explain some plant physics ('Symplast').

This article until now seems (I admit I have not yet read it completely, so might err) to talk only about muscles, human diseases etc.

Would be good if plant section could be added or they be mentioned in the overview so people transferred to here ((with a headache ;-) from botanist-expert-language-packed pages *gg* )) feel they get some explanation to their topic here, too (if not through much more than looking at the pictures, picking up some sentences about how it works in mammals and make a guess about similarities in plants in their own heads.) Doesn't have to be detailed, I guess; just naming the lifeforms in which similar structures of the same name can be also found - but not hidden somewhere in the middle or at the end of the article, but at a prominent place, in an "early" sentence (or, if perceived as better (but I don't think so), in a disclaimer(-template-thingy),) would be already sufficient for not feeling completely lost (pointed a wrong way/ dead end by such a link as I followed), in case no-one can contribute more. 2A02:3033:9:5D00:1:1:4A67:7EB7 (talk) 10:46, 5 August 2022 (UTC)[reply]

Ref:

• doi:10.1038/s41586-022-05550-y Actin cytoskeleton and complex cell architecture in an Asgard archaeon

Ernsts (talk) 09:14, 22 December 2022 (UTC)[reply]

The pointed (-) end and the barbed (+) end of actin are correctly described in the text: "The exposed areas of subdomains I and III are referred to as the 'barbed' ends, while the exposed areas of domains II and IV are termed the 'pointed' ends."

In the image, the labels are swapped. 69.166.46.174 (talk) 22:22, 2 May 2024 (UTC)[reply]