TSPAN6

TSPAN6
Identifiers
Aliases	TSPAN6, T245, TM4SF6, TSPAN-6, tetraspanin 6
External IDs	OMIM: 300191; MGI: 1926264; HomoloGene: 20700; GeneCards: TSPAN6; OMA:TSPAN6 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	100,639,991 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	132,799,178 bp
RNA expression pattern
	Top expressed in
	sperm; ; parotid gland; ; bronchial epithelial cell; ; nasal epithelium; ; epithelium of nasopharynx; ; tibia; ; mucosa of paranasal sinus; ; olfactory zone of nasal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon;
	Top expressed in
	saccule; ; transitional epithelium of urinary bladder; ; otic placode; ; otic vesicle; ; endocardial cushion; ; atrioventricular valve; ; medial ganglionic eminence; ; molar; ; abdominal wall; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity;
Cellular component	integral component of membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of NIK/NF-kappaB signaling; cell surface receptor signaling pathway; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7105
	56496
	ENSG00000000003
	ENSMUSG00000067377
	O43657
	O70401
	NM_001278740; NM_001278741; NM_001278742; NM_001278743; NM_003270
	NM_019656
	NP_001265669; NP_001265670; NP_001265671; NP_001265672; NP_003261
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.^[5]^[6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000000003 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maeda K, Matsuhashi S, Hori K, Xin Z, Mukai T, Tabuchi K, Egashira M, Niikawa N (Dec 1998). "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22". Genomics. 52 (2): 240–2. doi:10.1006/geno.1998.5415. PMID 9782095.
^ ^a ^b "Entrez Gene: TSPAN6 tetraspanin 6".

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000000003 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9782095-5] Maeda K, Matsuhashi S, Hori K, Xin Z, Mukai T, Tabuchi K, Egashira M, Niikawa N (Dec 1998). "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22". Genomics. 52 (2): 240–2. doi:10.1006/geno.1998.5415. PMID 9782095.

[entrez-6] "Entrez Gene: TSPAN6 tetraspanin 6".

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[2]

[3]

[4]

[5]

[6]

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

References

Further reading