PRIM1

PRIM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BPU, 4BPW, 4BPX, 4LIK, 4LIL, 4MHQ, 4RR2, 5EXR
Identifiers
Aliases	PRIM1, p49, primase (DNA) subunit 1, DNA primase subunit 1
External IDs	OMIM: 176635; MGI: 97757; HomoloGene: 730; GeneCards: PRIM1; OMA:PRIM1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,752,374 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,865,906 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; ganglionic eminence; ; ventricular zone; ; bone marrow; ; bone marrow cells; ; rectum; ; Achilles tendon; ; lymph node; ; islet of Langerhans;
	Top expressed in
	medial ganglionic eminence; ; fetal liver hematopoietic progenitor cell; ; genital tubercle; ; vas deferens; ; maxillary prominence; ; primitive streak; ; mandibular prominence; ; internal carotid artery; ; condyle; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; transferase activity; nucleotidyltransferase activity; metal ion binding; single-stranded DNA binding; DNA primase activity;
Cellular component	membrane; nucleoplasm; alpha DNA polymerase:primase complex; primosome complex;
Biological process	DNA replication; G1 phase; DNA replication initiation; DNA replication, synthesis of RNA primer; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5557
	19075
	ENSG00000198056
	ENSMUSG00000025395
	P49642
	P20664
	NM_000946
	NM_008921
	NP_000937
	NP_032947
	Wikidata
View/Edit Human	View/Edit Mouse

DNA primase small subunit is an enzyme that in humans is encoded by the PRIM1 gene.^[5]

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198056 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025395 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.

External links

Overview of all the structural information available in the PDB for UniProt: P49642 (Human DNA primase small subunit (PRIM1)) at the PDBe-KB.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198056 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025395 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530050-5] Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.

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References

Further reading

External links