P2RY13

P2RY13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B6U
Identifiers
Aliases	P2RY13, GPCR1, GPR86, GPR94, P2Y13, SP174, FKSG77, purinergic receptor P2Y13
External IDs	OMIM: 606380; MGI: 1921441; HomoloGene: 12543; GeneCards: P2RY13; OMA:P2RY13 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	151,329,549 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	59,118,303 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; bone marrow; ; trabecular bone; ; bone marrow cells; ; appendix; ; lymph node; ; testicle;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; spleen; ; lumbar subsegment of spinal cord; ; Region I of hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; bone marrow; ; visual cortex; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; endoplasmic reticulum; membrane;
Biological process	cellular response to organic cyclic compound; negative regulation of adenylate cyclase activity; signal transduction; G protein-coupled purinergic nucleotide receptor signaling pathway; G protein-coupled receptor signaling pathway; biological process;
	Sources:Amigo / QuickGO
Orthologs
	53829
	74191
	ENSG00000181631
	ENSMUSG00000036362
	Q9BPV8
	Q9D8I2
	NM_023914; NM_176894
	NM_028808
	NP_795713
	NP_083084
	Wikidata
View/Edit Human	View/Edit Mouse

P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene.^[5]^[6]^[7]

The product of this gene, P2Y₁₃, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181631 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036362 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wittenberger T, Schaller HC, Hellebrand S (Mar 2001). "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors". J Mol Biol. 307 (3): 799–813. doi:10.1006/jmbi.2001.4520. PMID 11273702.
^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
^ ^a ^b "Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13".

External links

"P2Y Receptors: P2Y₁₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181631 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036362 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11273702-5] Wittenberger T, Schaller HC, Hellebrand S (Mar 2001). "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors". J Mol Biol. 307 (3): 799–813. doi:10.1006/jmbi.2001.4520. PMID 11273702.

[pmid11574155-6] Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.

[entrez-7] "Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13".

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P2RY13

See also

References

Further reading

External links