Liprin-alpha-1

PPFIA1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1N7F
Identifiers
Aliases	PPFIA1, LIP.1, LIP1, LIPRIN, PTPRF interacting protein alpha 1
External IDs	OMIM: 611054; MGI: 1924750; HomoloGene: 20802; GeneCards: PPFIA1; OMA:PPFIA1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	70,385,312 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,107,466 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; oocyte; ; secondary oocyte; ; buccal mucosa cell; ; sperm; ; Achilles tendon; ; endothelial cell; ; Epithelium of choroid plexus; ; tibia; ; visceral pleura;
	Top expressed in
	zygote; ; secondary oocyte; ; genital tubercle; ; tail of embryo; ; primary oocyte; ; ventricular zone; ; superior cervical ganglion; ; lip; ; esophagus; ; hair follicle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity;
Cellular component	presynaptic active zone; focal adhesion; cytoplasm; cytosol; axon; dendrite; protein-containing complex;
Biological process	cell-matrix adhesion; negative regulation of stress fiber assembly; signal transduction; negative regulation of protein localization to plasma membrane; neurotransmitter secretion; glutamate secretion;
	Sources:Amigo / QuickGO
Orthologs
	8500
	233977
	ENSG00000131626; ENSG00000288198
	ENSMUSG00000037519
	Q13136
	n/a
	NM_003626; NM_177423; NM_001378006
	NM_001033319; NM_001195086
	NP_003617; NP_803172; NP_001364935
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[7]

Interactions

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 has been shown to interact with:

References

^ ^a ^b ^c ENSG00000288198 GRCh38: Ensembl release 89: ENSG00000131626, ENSG00000288198 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037519 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Aug 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–2838. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.
^ ^a ^b ^c ^d Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–15620. doi:10.1074/jbc.273.25.15611. PMID 9624153.
^ ^a ^b "Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1".
^ ^a ^b ^c Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
^ ^a ^b Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ ^a ^b ^c Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.

External links

Overview of all the structural information available in the PDB for UniProt: Q13136 (Liprin-alpha-1) at the PDBe-KB.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000288198 GRCh38: Ensembl release 89: ENSG00000131626, ENSG00000288198 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037519 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7796809-5] Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Aug 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–2838. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.

[pmid9624153-6] Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–15620. doi:10.1074/jbc.273.25.15611. PMID 9624153.

[entrez-7] "Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1".

[pmid12923177-8] Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.

[pmid12629171-9] Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid8524829-11] Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.

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Function

Interactions

References

Further reading

External links