KLK8

KLK8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NPM
Identifiers
Aliases	KLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein related peptidase 8
External IDs	OMIM: 605644; MGI: 1343327; HomoloGene: 21410; GeneCards: KLK8; OMA:KLK8 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,002,711 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,453,250 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; testicle; ; right uterine tube; ; vagina; ; human penis; ; oral cavity; ; minor salivary glands; ; vulva; ; gonad;
	Top expressed in
	lip; ; esophagus; ; superior surface of tongue; ; skin of external ear; ; vas deferens; ; embryo; ; embryo; ; epiblast; ; skin of abdomen; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; protein binding; hydrolase activity;
Cellular component	cytoplasm; extracellular region; extracellular space; serine protease inhibitor complex; secretory granule;
Biological process	synapse organization; keratinocyte proliferation; negative regulation of axon regeneration; neuron projection morphogenesis; cell death; memory; response to wounding; negative regulation of myelination; regulation of synapse organization; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	11202
	259277
	ENSG00000129455
	ENSMUSG00000064023
	O60259
	Q61955
	NM_001281431; NM_007196; NM_144505; NM_144506; NM_144507
	NM_008940; NM_001324398
	NP_001268360; NP_009127; NP_653088; NP_653089; NP_653090
	NP_001311327; NP_032966
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.^[5]^[6]^[7]^[8]^[9]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129455 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000064023 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N (May 1999). "A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain". Eur J Biochem. 260 (3): 627–34. doi:10.1046/j.1432-1327.1999.00213.x. PMID 10102990.
^ Yoshida S, Taniguchi M, Hirata A, Shiosaka S (Aug 1998). "Sequence analysis and expression of human neuropsin cDNA and gene". Gene. 213 (1–2): 9–16. doi:10.1016/S0378-1119(98)00232-7. PMID 9714609.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
^ ^a ^b "Entrez Gene: KLK8 kallikrein-related peptidase 8".

External links

The MEROPS online database for peptidases and their inhibitors: S01.244

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129455 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000064023 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10102990-5] Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N (May 1999). "A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain". Eur J Biochem. 260 (3): 627–34. doi:10.1046/j.1432-1327.1999.00213.x. PMID 10102990.

[pmid9714609-6] Yoshida S, Taniguchi M, Hirata A, Shiosaka S (Aug 1998). "Sequence analysis and expression of human neuropsin cDNA and gene". Gene. 213 (1–2): 9–16. doi:10.1016/S0378-1119(98)00232-7. PMID 9714609.

[pmid16800724-7] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-8] Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-9] "Entrez Gene: KLK8 kallikrein-related peptidase 8".

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v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

References

Further reading

External links