Dystrobrevin beta

DTNB
Identifiers
Aliases	DTNB, dystrobrevin beta
External IDs	OMIM: 602415; MGI: 1203728; HomoloGene: 74875; GeneCards: DTNB; OMA:DTNB - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	25,673,647 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	3,831,796 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right frontal lobe; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; amygdala; ; Brodmann area 10; ; nucleus accumbens; ; salivary gland;
	Top expressed in
	superior frontal gyrus; ; Rostral migratory stream; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; right kidney; ; genital tubercle; ; primary visual cortex; ; lacrimal gland; ; granulocyte; ; seminiferous tubule;
	More reference expression data
	n/a
Orthologs
	1838
	13528
	ENSG00000138101
	ENSMUSG00000071454
	O60941
	O70585
NM_001256303; NM_001256304; NM_001256308; NM_021907; NM_033147;
	NM_033148; NM_183360; NM_183361; NM_001320932; NM_001320933; NM_001320934; NM_001320935; NM_001320936; NM_001320937; NM_001351381; NM_001351382; NM_001351383; NM_001351384; NM_001351385; NM_001351386; NM_001351387; NM_001351388; NM_001351389; NM_001351390; NM_001351391; NM_001351392; NM_001351393; NM_001351394; NM_001351395; NM_001394686
	NM_001162465; NM_007886; NM_001355528; NM_001374710
NP_001243232; NP_001243233; NP_001243237; NP_001307861; NP_001307862;
	NP_001307863; NP_001307864; NP_001307865; NP_001307866; NP_068707; NP_149159; NP_149160; NP_899204; NP_899205; NP_001338310; NP_001338311; NP_001338312; NP_001338313; NP_001338314; NP_001338315; NP_001338316; NP_001338317; NP_001338318; NP_001338319; NP_001338320; NP_001338321; NP_001338322; NP_001338323; NP_001338324
	NP_001155937; NP_031912; NP_001342457; NP_001361639
	Wikidata
View/Edit Human	View/Edit Mouse

Dystrobrevin beta is a protein which in humans is encoded by the DTNB gene.^[5]

Function

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138101 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071454 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Blake DJ, Nawrotzki R, Loh NY, Górecki DC, Davies KE (January 1998). "beta-dystrobrevin, a member of the dystrophin-related protein family". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 241–6. Bibcode:1998PNAS...95..241B. doi:10.1073/pnas.95.1.241. PMC 18188. PMID 9419360.
^ "Entrez Gene: DTNB dystrobrevin, beta".

Blake DJ, Hawkes R, Benson MA, Beesley PW (1999). "Different dystrophin-like complexes are expressed in neurons and glia". J. Cell Biol. 147 (3): 645–58. doi:10.1083/jcb.147.3.645. PMC 2151186. PMID 10545507.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Piluso G, Mirabella M, Ricci E, et al. (2000). "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells". J. Biol. Chem. 275 (21): 15851–60. doi:10.1074/jbc.M000439200. PMID 10747910.
Puca AA, Nigro V, Piluso G, et al. (1998). "Identification and characterization of a novel member of the dystrobrevin gene family". FEBS Lett. 425 (1): 7–13. doi:10.1016/S0014-5793(98)00097-0. PMID 9540997. S2CID 31934419.
Macioce P, Gambara G, Bernassola M, et al. (2003). "Beta-dystrobrevin interacts directly with kinesin heavy chain in brain". J. Cell Sci. 116 (Pt 23): 4847–56. doi:10.1242/jcs.00805. PMID 14600269. S2CID 27097248.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Straub V, Campbell KP (1997). "Muscular dystrophies and the dystrophin-glycoprotein complex". Curr. Opin. Neurol. 10 (2): 168–75. doi:10.1097/00019052-199704000-00016. PMID 9146999.
Nazarian R, Starcevic M, Spencer MJ, Dell'Angelica EC (2006). "Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein". Biochem. J. 395 (3): 587–98. doi:10.1042/BJ20051965. PMC 1462696. PMID 16448387.
Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951. S2CID 3005450.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Albrecht DE, Froehner SC (2004). "DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes". J. Biol. Chem. 279 (8): 7014–23. doi:10.1074/jbc.M312205200. PMID 14623885.
Peters MF, O'Brien KF, Sadoulet-Puccio HM, et al. (1997). "beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations". J. Biol. Chem. 272 (50): 31561–9. doi:10.1074/jbc.272.50.31561. PMID 9395493.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Benson MA, Newey SE, Martin-Rendon E, et al. (2001). "Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain". J. Biol. Chem. 276 (26): 24232–41. doi:10.1074/jbc.M010418200. PMID 11316798.
Hillman RT, Green RE, Brenner SE (2004). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138101 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071454 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9419360-5] Blake DJ, Nawrotzki R, Loh NY, Górecki DC, Davies KE (January 1998). "beta-dystrobrevin, a member of the dystrophin-related protein family". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 241–6. Bibcode:1998PNAS...95..241B. doi:10.1073/pnas.95.1.241. PMC 18188. PMID 9419360.

[entrez-6] "Entrez Gene: DTNB dystrobrevin, beta".

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Function

References

Further reading