Farnesyl pyrophosphate

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Farnesyl pyrophosphate

Identifiers
CAS Number	13058-04-3
MeSH	farnesyl+pyrophosphate
PubChem CID	706
CompTox Dashboard (EPA)	DTXSID701020624
Properties
Chemical formula	C15H28O7P2
Molar mass	382.326
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Farnesyl pyrophosphate (FPP) is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes, terpenoids, and sterols.

It is the immediate precursor of squalene (via the enzyme squalene synthase), dehydrodolichol diphosphate (a precursor of dolichol), and geranylgeranyl pyrophosphate (GGPP).

Farnesyl pyrophosphate synthase (a prenyl transferase) catalyzes sequential condensation reactions of dimethylallyl pyrophosphate with 2 units of 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate.

• Dimethylallyl pyrophosphate reacts with 3-isopentenyl pyrophosphate to form geranyl pyrophosphate:

• Geranyl pyrophosphate itself reacts with 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate

The above reactions are inhibited by bisphosphonates (used for osteoporosis).

• Farnesene
• Farnesol
• Geranyl pyrophosphate
• Geranylgeranyl pyrophosphate

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