- Sulfapyridine
-
Sulfapyridine Systematic (IUPAC) name 4-amino-N-pyridin-2-ylbenzenesulfonamide Clinical data AHFS/Drugs.com Micromedex Detailed Consumer Information MedlinePlus a682204 Pregnancy cat. ? Legal status ? Identifiers CAS number 000144-83-2 ATC code J01EB04 QJ01EQ04 PubChem CID 5336 DrugBank DB00891 ChemSpider 5145 UNII Y5V2N1KE8U KEGG D02434 ChEBI CHEBI:132842 ChEMBL CHEMBL700 Chemical data Formula C11H11N3O2S Mol. mass 249.29 g/mol SMILES eMolecules & PubChem - InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
Key:GECHUMIMRBOMGK-UHFFFAOYSA-N
(what is this?) (verify)
Sulfapyridine, original UK spelling Sulphapyridine, is a sulfonamide antibacterial. At one time it was commonly referred to as M&B.
Sulfapyridine is not prescribed for treatment in humans any more. However, it may be used to treat Linear IgA Disease. It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage.
Discovered by May & Baker Ltd and logged in their Test Book on 2 November 1937 under Code No M&B693[1]. Successfully used to treat Winston Churchill's bacterial pneumonia in 1942. In a subsequent radio broadcast he said "This admirable M&B from which I did not suffer any inconvenience, was used at the earliest moment and, after a week's fever, the intruders were repulsed." In 1944 M&B693 also saved Nero, the Royal Circus lion, from pneumonia.[Glasgow Evening News January 1944.]
The drug sulfasalazine is structurally one molecule of mesalamine linked to one molecule of Sulfapyridine with an azo bond.
References
Antibacterials: nucleic acid inhibitors (J01E, J01M) Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)Sulfonamides
(DHPS inhibitor)Sulfaisodimidine • Sulfamethizole • Sulfadimidine • Sulfapyridine • Sulfafurazole • Sulfanilamide (Prontosil) • Sulfathiazole • SulfathioureaOther/ungroupedCombinationsTopoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)1st g.2nd g.Ciprofloxacin# • Enoxacin‡ • Fleroxacin‡ • Lomefloxacin • Nadifloxacin • Ofloxacin • Norfloxacin • Pefloxacin • Rufloxacin3rd g.4th g.Besifloxacin • Clinafloxacin† • Garenoxacin • Gemifloxacin • Moxifloxacin • Gatifloxacin‡ • Sitafloxacin • Trovafloxacin‡/Alatrofloxacin‡ • PrulifloxacinVet.Related (DG)Anaerobic DNA
inhibitorsNitrofuran derivativesRNA synthesis This systemic antibacterial-related article is a stub. You can help Wikipedia by expanding it. - InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)