DEBS 2022 is the sixteenth in a series that spans 20 years of history, with 15 past editions as a conference and five editions as a workshop co-located with major conferences. The objectives of the ACM International Conference on Distributed and Event-Based Systems (DEBS) have been to provide a forum dedicated to the dissemination of original research, the discussion of practical insights, and the reporting of experiences relevant to distributed systems and event-based computing. The conference provides a forum for academia and industry to exchange ideas through its tutorials, research papers, and the grand challenge. Recently, the ACM International Conference on Distributed and Event-Based Systems, including DEBS 2022, has become the premier venue for cutting-edge research in the integration of distributed and event-based systems in relevant domains such as Big Data, AI, ML, IoT, and Blockchain.