article

Automated algorithms for multiscale morphometry of neuronal dendrites

Authors:

Christina M. Weaver,

Patrick R. Hof,

Susan L. Wearne,

W. Brent LindquistAuthors Info & Claims

Neural Computation, Volume 16, Issue 7

Pages 1353 - 1383

https://doi.org/10.1162/089976604323057425

Published: 01 July 2004 Publication History

Abstract

We describe the synthesis of automated neuron branching morphology and spine detection algorithms to provide multiscale three-dimensional morphological analysis of neurons. The resulting software is applied to the analysis of a high-resolution (0.098 µm × 0.098 µm × 0.081 µm) image of an entire pyramidal neuron from layer III of the superior temporal cortex in rhesus macaque monkey. The approach provides a highly automated, complete morphological analysis of the entire neuron; each dendritic branch segment is characterized by several parameters, including branch order, length, and radius as a function of distance along the branch, as well as by the locations, lengths, shape classification (e.g., mushroom, stubby, thin), and density distribution of spines on the branch. Results for this automated analysis are compared to published results obtained by other computer-assisted manual means.

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Cited By

Song SSon JKim M(2010)Stitching of microscopic images for quantifying neuronal growth and spine plasticityProceedings of the 6th international conference on Advances in visual computing - Volume Part I10.5555/1939921.1939927(45-53)Online publication date: 29-Nov-2010
https://dl.acm.org/doi/10.5555/1939921.1939927
Song SSon JKim M(2010)Stitching of Microscopic Images for Quantifying Neuronal Growth and Spine PlasticityAdvances in Visual Computing10.1007/978-3-642-17289-2_5(45-53)Online publication date: 29-Nov-2010
https://dl.acm.org/doi/10.1007/978-3-642-17289-2_5
Ikeno HKanzaki RAonuma HTakahata MMizunami MYasuyama KMatsui NYokohari FUsui S(2007)Development of Invertebrate Brain Platform: Management of Research Resources for Invertebrate Neuroscience and NeuroethologyNeural Information Processing10.1007/978-3-540-69162-4_94(905-914)Online publication date: 13-Nov-2007
https://dl.acm.org/doi/10.1007/978-3-540-69162-4_94

Index Terms

Automated algorithms for multiscale morphometry of neuronal dendrites
1. Applied computing
  1. Life and medical sciences
2. Computing methodologies
  1. Artificial intelligence
    1. Computer vision
      1. Computer vision problems
        Object recognition
      2. Computer vision representations
        Shape representations
  2. Machine learning
    1. Machine learning approaches
      1. Neural networks

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cover image Neural Computation

Neural Computation Volume 16, Issue 7

July 2004

215 pages

ISSN:0899-7667

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MIT Press

Cambridge, MA, United States

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Published: 01 July 2004

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Cited By

Song SSon JKim M(2010)Stitching of microscopic images for quantifying neuronal growth and spine plasticityProceedings of the 6th international conference on Advances in visual computing - Volume Part I10.5555/1939921.1939927(45-53)Online publication date: 29-Nov-2010
https://dl.acm.org/doi/10.5555/1939921.1939927
Song SSon JKim M(2010)Stitching of Microscopic Images for Quantifying Neuronal Growth and Spine PlasticityAdvances in Visual Computing10.1007/978-3-642-17289-2_5(45-53)Online publication date: 29-Nov-2010
https://dl.acm.org/doi/10.1007/978-3-642-17289-2_5
Ikeno HKanzaki RAonuma HTakahata MMizunami MYasuyama KMatsui NYokohari FUsui S(2007)Development of Invertebrate Brain Platform: Management of Research Resources for Invertebrate Neuroscience and NeuroethologyNeural Information Processing10.1007/978-3-540-69162-4_94(905-914)Online publication date: 13-Nov-2007
https://dl.acm.org/doi/10.1007/978-3-540-69162-4_94

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