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Artificial intelligence design of ProteinA-like peptides

Published: 28 June 2024 Publication History

Abstract

There are hundreds of millions of natural proteins in nature, and these natural proteins can play different roles due to their special structure. The first field of AI for Science is the prediction and design of protein structure, and simulating the structure of certain natural proteins has become a popular topic in biopharmaceutical research. The generative adversarial network model in deep learning and a target sequence method were used in the paper to mimic the special structure of natural proteins. We successfully synthesized the ProteinA-like peptide sequence which had a high structural similarity with the natural proteins in its tertiary structure.These synthetic peptide sequences by computer will lay the foundation for the later transcription to become mRNA and to synthesize protein in the laboratory .

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    BIC '24: Proceedings of the 2024 4th International Conference on Bioinformatics and Intelligent Computing
    January 2024
    504 pages
    ISBN:9798400716645
    DOI:10.1145/3665689
    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than the author(s) must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected].

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    Published: 28 June 2024

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