research-article

Comparison of virus interactions with human signal transduction pathways

Authors:

Judith Klein-SeetharamanAuthors Info & Claims

BCB '10: Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology

Pages 17 - 24

https://doi.org/10.1145/1854776.1854785

Published: 02 August 2010 Publication History

Abstract

Viruses depend on their hosts at every stage of their life cycles and must therefore communicate with them via protein-protein interactions (PPI). To investigate the mechanisms of communication by different viruses, we overlay reported pairwise human, virus PPI on human signaling pathways. Of 671 pathways obtained from NCI and Reactome databases, 355 are potentially targeted by at least one virus. The majority (268) of pathways is linked to more than one virus and a large number of the proteins frequently targeted by viruses are already known drug targets. We find qualitative evidence for the hypothesis that the proteins that viruses are interacting with in each pathway are not necessarily the same. For example, the pathway involved most frequently in an interaction with any virus, the TGF-β pathway, is linked by 18 viruses involving 50 different proteins, and none of these proteins is known to bind to proteins derived from all 18 viruses. Thus, our analysis provides biological hypotheses that can be tested quantitatively by statistical means and validated experimentally.

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Cited By

Durmuş SÜlgen K(2017) Comparative interactomics for virus–human protein–protein interactions: DNA viruses versus RNA viruses FEBS Open Bio10.1002/2211-5463.121677:1(96-107)Online publication date: 4-Jan-2017
https://doi.org/10.1002/2211-5463.12167
Sen RNayak LDe R(2016)A review on host–pathogen interactions: classification and predictionEuropean Journal of Clinical Microbiology & Infectious Diseases10.1007/s10096-016-2716-735:10(1581-1599)Online publication date: 29-Jul-2016
https://doi.org/10.1007/s10096-016-2716-7
DurmuÅŸ SÃ‡akÄ±r TÃ–zgÃ¼r AGuthke R(2015)A review on computational systems biology of pathogenâ€“host interactionsFrontiers in Microbiology10.3389/fmicb.2015.002356Online publication date: 9-Apr-2015
https://doi.org/10.3389/fmicb.2015.00235

Index Terms

Comparison of virus interactions with human signal transduction pathways
1. Applied computing
  1. Life and medical sciences

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cover image ACM Conferences

BCB '10: Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology

August 2010

705 pages

ISBN:9781450304382

DOI:10.1145/1854776

General Chairs:
Aidong Zhang
SUNY at Buffalo
,
Mark Borodovsky
Georgia Tech
,
Program Chairs:
Gultekin Ozsoyoglu
Case Western Reserve University
,
Armin Mikler
University of North Texas

Copyright © 2010 ACM.

Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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Published: 02 August 2010

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BCB'10: ACM International Conference on Bioinformatics and Computational Biology

August 2 - 4, 2010

New York, Niagara Falls

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Cited By

Durmuş SÜlgen K(2017) Comparative interactomics for virus–human protein–protein interactions: DNA viruses versus RNA viruses FEBS Open Bio10.1002/2211-5463.121677:1(96-107)Online publication date: 4-Jan-2017
https://doi.org/10.1002/2211-5463.12167
Sen RNayak LDe R(2016)A review on host–pathogen interactions: classification and predictionEuropean Journal of Clinical Microbiology & Infectious Diseases10.1007/s10096-016-2716-735:10(1581-1599)Online publication date: 29-Jul-2016
https://doi.org/10.1007/s10096-016-2716-7
DurmuÅŸ SÃ‡akÄ±r TÃ–zgÃ¼r AGuthke R(2015)A review on computational systems biology of pathogenâ€“host interactionsFrontiers in Microbiology10.3389/fmicb.2015.002356Online publication date: 9-Apr-2015
https://doi.org/10.3389/fmicb.2015.00235

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