Coregistration of small animal PET and autoradiography for in vivo-ex vivo comparison
Authors: 
Soo-Min Song, Min-Jeong Kim, Joung-Min Lee, Hye-Jin Park, KyeongMin Kim, Gi-Jeong Cheon, Myoung-Hee KimAuthors Info & Claims
Abstract
Non-invasive imaging of small animal and its quantification techniques are needed to be evaluated by comparison with ex vivo image. To overcome the existing method, hand-operated comparison with the unaided eye observation, we present an algorithm that matches the target area in PET scanned in vivo with an autoradiography image acquired ex vivo. We applied a coregistration algorithm that uses voxel similarity to find the corresponding slices and to make quantitative measurements. Automatic matching of in vivo and ex vivo images is novel, and can provide better validation than manual matching techniques.
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Sponsors
- AChiRP: Chilean Association for Pattern Recognition
- USM: Technical University Federico Santa María
- 3IE: The International Institute for Innovation and Entrepreneurship
- USACH: University of Santiago de Chile
- SEPARI: The Southeastern Pacific Research Institute for Advanced Technologies
Publisher
Springer-Verlag
Berlin, Heidelberg
Publication History
Published: 13 November 2007
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