SALINOMYCIN, A NEW POLYETHER ANTIBIOTIC

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

YUKIO MIYAZAKI, MITSUO SHIBUYA, HIDEO SUGAWARA, OSAMU KAWAGUCHI, CHIEKO HIROSE, JUNSAKU NAGATSU, SHINICHIRO ESUMI

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1974 Volume 27 Issue 11 Pages 814-821

DOI https://doi.org/10.7164/antibiotics.27.814

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Abstract

Salinomycin is a new polyether antibiotic produced by a strain of Streptomyces albus (ATCC 21838). The antibiotic is purified by solvent extraction followed by chromatography on alumina or silica gel. It is a weakly acidic compound and has the molecular formula C₄₂H₇₀O₁₁. Salinomycin exhibits activity against gram-positive bacteria including mycobacteria and some filamentous fungi. and is effective in the treatment of coccidial infection of poultry.

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