In this paper, we study the three-dimensional axisymmetric Navier-Stokes system with nonzero swirl. By establishing a new key inequality for the pair $(\frac{ω^{r}}{r},\frac{ω^{θ}}{r})$, we get several Prodi-Serrin type regularity criteria based on the angular velocity, $u^θ$. Moreover, we obtain the global well-posedness result if the initial angular velocity $u_{0}^{θ}$ is appropriate small in the critical space $L^{3}(\mathbb{R}^{3})$. Furthermore, we also get several Prodi-Serrin type regularity criteria based on one component of the solutions, say $ω^3$ or $u^3$.
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