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A mixed-methods systematic review of post-viral fatigue interventions: Are there lessons for long Covid?

Fig 2

Mean differences (95% Confidence Intervals (CI), Inverse Variance (IV)) for fatigue in studies assessing the effectiveness of interventions for reducing fatigue severity.

Fatigue is expressed on a 0–100 scale. Studies are ordered by the mean difference between the average score of participants in the intervention group and participants in the control group. The baseline fatigue severity of each group and the effect size (standardised mean difference (SMD, Cohen’s d and Hedges’ g)) of each intervention is also listed. ǂ = non-inferiority trial to see if one treatment is no less effective than the other, ¥ = fatigued individuals vs healthy controls.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0259533.g002