The Effects of CFTR and Mucoid Phenotype on Susceptibility and Innate Immune Responses in a Mouse Model of Pneumococcal Lung Disease
Fig 1
The effect of CFTR on bacterial clearance.
CFTR–/– mice (solid boxes) and WT- mice (open boxes) were infected with 7x105 CFU of Sp strain CHB756, CHB1058, or WU2 (n = 8–10) or 1x105 CFU of Sp strain CHB1126 (n = 6). CFUs were quantified from lung homogenates (A) and BAL fluid (B) 5 days post-infection. Each data point represents one mouse. The horizontal lines indicate the median for each group. CFTR–/– mice and WT-mice were directly compared for each strain using the Mann- Whitney (two-tailed) Test on ranked data (as described in the methods). P-values are for comparisons between WT and CFTR–/– mice in each treatment group, Experiments were repeated at least twice. P-values ≥ 0.05 are not shown. Statistical comparisons between results with different challenge strains are listed in Table 2.