Effects of Nutritional Supplementation on Fatigue, and Autonomic and Immune Dysfunction in Patients with End-Stage Renal Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Fig 3
Changes in HHV6 and 7 reactivation following nutritional supplementation in patients with ESRD (0–12 weeks).
Differences of changes in the number of copies of (a) HHV6 and (b) HHV7 DNA were determined via the Mann–Whitney test by treatment groups, placebo and nutritional drink (HHV6, Z = −6.08, P = 0.54 and Z = −0.18, P = 0.86 and HHV7, Z = −0.62, P = 0.54 and Z = −2.43, P = 0.016, respectively). We performed the statistical analysis for the samples that exceeded the detection limits, thereafter, the number of participants with these parameters were smaller than in the total samples (HHV6, 23 in the placebo and 22 in the nutritional drink groups, and HHV7, 50 in the placebo and 60 in the nutritional drink groups). Error bars represent the standard error of the mean.