Normal Leptin Expression, Lower Adipogenic Ability, Decreased Leptin Receptor and Hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis
Figure 4
The expression of leptin receptor in induced adipocytes was determined by immunocytochemistry.
The AIS MSCs (a) was from a 14-year-old boy (Cobb angle = 80°) and the normal control (b) was from a 19-year-old boy. Note that the leptin receptors were abundant in undifferentiated MSCs from control sample, but were rare in those from AIS sample. Scale bar = 200 µm.