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Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons

Fig 6

Model generalization.

(A) Responses to a ramp current injection in burst mode (left) and tonic mode (right). (B) Responses to a noise current generated according to an Ornstein-Uhlenbeck process and scaled based on the excitability of the different experimental cells and models (see Methods). (C) Generalization errors for all the models that passed the generalization test (all generalization errors <3 STD). (D) Proportion of models that passed the generalization test (see S4 Fig for examples of models that failed this test).

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1006753.g006