Anti-plasmodial and Cholinesterase Inhibiting Activities of some Constituents of <i>Psorospermum glaberrimum</i>

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Anti-plasmodial and Cholinesterase Inhibiting Activities of some Constituents of Psorospermum glaberrimum

Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1">Bruno Ndjakou Lenta, Institute of Forestry, Tribhuvan University">Krishna Prasad Devkota, Silvère Ngouela, Fabrice Fekam Boyom, Quamar Naz, Muhammad Iqbal Choudhary, Etienne Tsamo, Philip Jon Rosenthal, Norbert Sewald

Author information

Bruno Ndjakou Lenta
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University
Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1
Krishna Prasad Devkota
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University
Institute of Forestry, Tribhuvan University
Silvère Ngouela
Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1
Fabrice Fekam Boyom
Department of Biochemistry, Faculty of Science, University of Yaoundé
Quamar Naz
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi
Muhammad Iqbal Choudhary
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi
Etienne Tsamo
Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1
Philip Jon Rosenthal
Division of Infectious Diseases, Department of Medicine, University of California
Norbert Sewald
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University

Keywords: Psorospermum glaberrimum, Hypericaceae, anthranoid, anti-plasmodial, cholinesterase inhibition

JOURNAL FREE ACCESS

2008 Volume 56 Issue 2 Pages 222-226

DOI https://doi.org/10.1248/cpb.56.222

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Abstract

Glaberianthrone (1), a new bianthrone was isolated from the hexane extract of the stem bark of Psorospermum glaberrimum together with thirteen known compounds: 3-geranyloxyemodin anthrone (2), friedelan-3-one (3), 3-prenyloxyemodin anthrone (4), 3-geranyloxyemodin (5), 3-prenyloxyemodin (6), friedelan-3-ol (7), acetylvismione D (8), betulinic acid (9), 2-geranylemodin (10), bianthrone A2b (11), bianthrone 1a (12), emodin (13) and 2-prenylemodin (14). The structures of the isolated compounds were established by means of spectroscopic methods. The extracts and the isolated compounds were tested in vitro for their anti-plasmodial activity against Plasmodium falciparum (chloroquine resistant strain W2) and for their acetyl- and butyrylcholinesterase inhibitory properties. The n-hexane extract showed good anti-plasmodial activity against P. falciparum W2 strain, with IC₅₀ of 0.87 μg/ml. It also exhibited 65.5% and 98.2% of acetyl- and butyrylcholinesterase inhibition at 0.2 mg/ml, respectively. Compounds 2 and 8 showed the best potencies against P. falciparum W2 strain with IC₅₀ of 1.68 μM and 0.12 μM, (0.66 μg/ml and 0.054 μg/ml) respectively. All tested compounds showed good butyrylcholinesterase inhibition activities with compound 12 displaying the best potency (IC₅₀ 9.25±0.25 μM). All the tested compounds showed weak inhibitory activity against acetylcholinesterase.

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