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Lysergic Acid Diethylamide (LSD-25)

XXXI. Comparison by questionnaire of psychotomimetic activity of congeners on normal subjects and drug addicts

Published online by Cambridge University Press:  08 February 2018

Harold A. Abramson
Harold A. Abramson*
Affiliation:
From the Biological Laboratory, Cold Spring Harbor, New York and the State Hospital, Central Islip, New York
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Extract

A generally acceptable method of comparing psychotomimetic compounds has apparently not been devised. A method of this type would provide the replicability not now available in the newly developed field of psycho-pharmacology. For example, the method employing the Cold Spring Harbor questionnaire devised by the writer and his co-workers has been criticized as being “too suggestible”, “too structured”, or “insufficiently cognizant of unconscious processing”. It is the purpose of this communication to show that the Cold Spring Harbor questionnaire (1, 2) provides a suitable method of study of the psychotomimetic drugs similar to d-lysergic acid diethylamide (LSD-25). The basis for this statement is the comparison made here of the results of an independent study of a series of congeners of LSD-25 made by Isbell, Miner and Logan (3) in another laboratory, in a different milieu, and on a different population sample. It has been found that the comparative effectiveness of a series of LSD congeners both at Cold Spring Harbor and at Isbell's laboratory in Lexington, Kentucky are the same when the Cold Spring Harbor questionnaire is employed.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 444 , July 1960 , pp. 1120 - 1123
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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References

1 Abramson, H. A., Jarvik, M. E., Kaufman, M. R., Kornetsky, C., Levine, A., and Wagner, M., “Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses”, J. Psychol, 1955, 39, 3.Google Scholar
2 Idem , “Lysergic Acid Diethylamide (LSD-25): XXX. The Questionnaire Technique with Notes on Its Use”, ibid. In press.Google Scholar
3 Isbell, H., Miner, E. J., and Logan, C. R., “Relationships of Psychotomimetic to Anti-Serotonin Potencies of Congeners of Lysergic Acid Diethylamide (LSD-25)”, Psychopharmacologia, 1959, 1, 20.CrossRefGoogle Scholar
4 Abramson, H. A., “Lysergic Acid Diethylamide (LSD-25): XXIX. The Response Index as a Measure of Threshold Activity of Psychotropic Drugs in Man”, J. Psychol, 1959, 48, 65.Google Scholar
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