Development of Hippocampal Replay with Learning in Spatial Memory of Precise Goal Locations
Authors: 
Li Zheng, Nan Zhu, Yimeng Wang, Xueling Wang, Ling Wang, Chenguang ZhengAuthors Info & Claims
Pages 275 - 281
Abstract
Hippocampal place cells replay spatial pathways in time-compressed sequences during sharp-wave ripples (SWRs), which supports the consolidation of spatial memory in rats. Our previous study found that the replay sequences developed a bias to represent the correct reward location. However, little is known about whether these replay sequences represent trajectories of past experience or future prediction in memory retrieval of the precise location. We detected replay events within SWRs and separated them into two types according to their preferred representing trajectories, clockwise (CW) event for the past trajectory and counterclockwise (CCW) event for the future trajectory. We found that the occurrence of replay event in the CCW direction increased as rats learned the task with improving performance. Furthermore, replay events of both trajectories exhibited more occurrence in correct trials than in error trials, with higher occurrence of CCW events than CW events. These results suggest that in the process of learning a precise reward location, the successful memory retrieval would be strongly correlated with the hippocampal replay sequences including information for future planning.
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- Development of Hippocampal Replay with Learning in Spatial Memory of Precise Goal Locations
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Published In
November 2022
306 pages
ISBN:9781450397223
DOI:10.1145/3574198
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Published: 15 March 2023
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- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin Municipality Foundation
- China Post-doctoral Science Foundation
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ICBBE 2022
ICBBE 2022: 2022 9th International Conference on Biomedical and Bioinformatics Engineering
November 10 - 13, 2022
Kyoto, Japan
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